| Gene Symbol | ERO1L |
|---|---|
| Entrez Gene | 30001 |
| Alt Symbol | ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1A, ERO1LA |
| Species | Human |
| Gene Type | protein-coding |
| Description | ERO1-like (S. cerevisiae) |
| Other Description | ERO1-like protein alpha|endoplasmic oxidoreductin-1-like protein|oxidoreductin-1-L-alpha |
| Swissprots | Q7LD45 Q9P1Q9 A8MYW1 A8K9X4 Q9UKV6 Q96HE7 |
| Accessions | EAW65646 EAW65647 Q96HE7 AF081886 AAF35260 AF123887 AAF06104 AK024224 AK292839 BAF85528 AY358463 AAQ88828 BC008674 AAH08674 BC012941 AAH12941 BX420309 CR990477 DR006292 GQ129372 ACT64506 GQ129373 ACT64507 HQ448296 ADQ32776 JF432168 ADZ15385 XM_011536684 XP_011534986 NM_014584 NP_055399 |
| Function | Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum. |
| Tissue Specificity | Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269|PubMed:10818100}. |
| Top Pathways | Vibrio cholerae infection, Protein processing in endoplasmic reticulum |