Gene Symbol | MILR1 |
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Entrez Gene | 284021 |
Alt Symbol | Allergin-1, C17orf60, MCA-32, MCA32 |
Species | Human |
Gene Type | protein-coding |
Description | mast cell immunoglobulin-like receptor 1 |
Other Description | allergin-1|allergy inhibitory receptor 1|mast cell antigen 32|probable mast cell antigen 32 homolog |
Swissprots | B7ZM50 B4DUS1 A1L458 B9EGN0 D6RUW6 D6RUW8 Q7Z6M3 |
Accessions | CAJ75916 CBY88425 Q7Z6M3 AB542950 BAJ08251 AB542951 BAJ08252 AB542952 BAJ08253 BC014523 BC018972 BC053534 AAH53534 BC130406 AAI30407 BC136594 AAI36595 BC144272 AAI44273 BE296352 CD687595 XM_005276872 XP_005276929 XM_005276874 XP_005276931 XM_005276875 XP_005276932 XM_005276876 XP_005276933 XM_005276877 XP_005276934 XM_005276878 XP_005276935 XM_011524627 XP_011522929 NM_001085423 NP_001078892 NM_001291316 NP_001278245 NM_001291317 NP_001278246 |
Function | Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE- mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:20526344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20526344}. |
Tissue Specificity | Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level). {ECO:0000269|PubMed:20526344}. |
C17orf60 CRISPR/Cas9 KO Plasmid (h) - sc-415350 from Santa Cruz Biotechnology
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C17orf60 HDR Plasmid (h) - sc-415350-HDR from Santa Cruz Biotechnology
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C17orf60 Double Nickase Plasmid (h) - sc-415350-NIC from Santa Cruz Biotechnology
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C17orf60 Double Nickase Plasmid (h2) - sc-415350-NIC-2 from Santa Cruz Biotechnology
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C17orf60 CRISPR Activation Plasmid (h) - sc-415350-ACT from Santa Cruz Biotechnology
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C17orf60 CRISPR Activation Plasmid (h2) - sc-415350-ACT-2 from Santa Cruz Biotechnology
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C17orf60 Lentiviral Activation Particles (h) - sc-415350-LAC from Santa Cruz Biotechnology
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C17orf60 Lentiviral Activation Particles (h2) - sc-415350-LAC-2 from Santa Cruz Biotechnology
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C17orf60 siRNA (h) - sc-94251 from Santa Cruz Biotechnology
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C17orf60 shRNA Plasmid (h) - sc-94251-SH from Santa Cruz Biotechnology
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C17orf60 shRNA (h) Lentiviral Particles - sc-94251-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4468 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4468 from Sigma-Aldrich
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MILR1 siRNA (Human) - CRJ6960 from Cohesion Biosciences
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shRNA set against Human Milr1 (NM_001085423.1) - SHH342027 from Creative biogene
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MILR1 shRNA Plasmid (Human) - CHJ6960 from Cohesion Biosciences
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