| Gene Symbol |
CHRNA10
|
| Entrez Gene |
57053
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cholinergic receptor, nicotinic, alpha 10 (neuronal)
|
| Other Description |
NACHR alpha-10|acetylcholine receptor, nicotinic, alpha 10 (neuronal)|cholinergic receptor, nicotinic, alpha polypeptide 10|neuronal acetylcholine receptor subunit alpha-10|nicotinic acetylcholine receptor subunit alpha-10
|
| Swissprots |
Q9GZZ6
|
| Accessions |
AAK14333 EAX02560 Q9GZZ6 AF199235 AAG00795 AJ278118 CAC20435 AJ295237 CAC16144 BC136250 AAI36251 BC143303 BC152764 AAI52765 XM_011520234 XP_011518536 NM_001303034 NP_001289963 NM_001303035 NP_001289964 NM_020402 NP_065135
|
| Function |
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO:0000269|PubMed:11752216}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. {ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:15531379}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|