CHRNA10
| Gene Symbol | CHRNA10 |
|---|---|
| Entrez Gene | 57053 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cholinergic receptor, nicotinic, alpha 10 (neuronal) |
| Other Description | NACHR alpha-10|acetylcholine receptor, nicotinic, alpha 10 (neuronal)|cholinergic receptor, nicotinic, alpha polypeptide 10|neuronal acetylcholine receptor subunit alpha-10|nicotinic acetylcholine receptor subunit alpha-10 |
| Swissprots | Q9GZZ6 |
| Accessions | AAK14333 EAX02560 Q9GZZ6 AF199235 AAG00795 AJ278118 CAC20435 AJ295237 CAC16144 BC136250 AAI36251 BC143303 BC152764 AAI52765 XM_011520234 XP_011518536 NM_001303034 NP_001289963 NM_001303035 NP_001289964 NM_020402 NP_065135 |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO:0000269|PubMed:11752216}. |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. {ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:15531379}. |
| Top Pathways | Neuroactive ligand-receptor interaction |
AChRα10 CRISPR/Cas9 KO Plasmid (h) - sc-408076 from Santa Cruz Biotechnology
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AChRα10 HDR Plasmid (h) - sc-408076-HDR from Santa Cruz Biotechnology
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AChRα10 Double Nickase Plasmid (h) - sc-408076-NIC from Santa Cruz Biotechnology
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AChRα10 Double Nickase Plasmid (h2) - sc-408076-NIC-2 from Santa Cruz Biotechnology
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AChRα10 CRISPR Activation Plasmid (h) - sc-408076-ACT from Santa Cruz Biotechnology
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AChRα10 CRISPR Activation Plasmid (h2) - sc-408076-ACT-2 from Santa Cruz Biotechnology
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AChRα10 Lentiviral Activation Particles (h) - sc-408076-LAC from Santa Cruz Biotechnology
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AChRα10 Lentiviral Activation Particles (h2) - sc-408076-LAC-2 from Santa Cruz Biotechnology
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AChRα10 siRNA (h) - sc-105030 from Santa Cruz Biotechnology
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AChRα10 shRNA Plasmid (h) - sc-105030-SH from Santa Cruz Biotechnology
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AChRα10 shRNA (h) Lentiviral Particles - sc-105030-V from Santa Cruz Biotechnology
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Nicotinic Acetylcholine R alpha 10/CHRNA10 RNAi - H00057053-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6096 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6096 from Sigma-Aldrich
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CHRNA10 siRNA (Human) - CRJ1302 from Cohesion Biosciences
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CHRNA10 - MBS8223553 from MyBioSource
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shRNA set against Human CHRNA10 (NM_020402.2) - SHH263525 from Creative biogene
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shRNA set against Human CHRNA10(NM_020402.2) - SHG176817 from Creative biogene
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Human CHRNA10 siRNA - orb271803 from Biorbyt
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CHRNA10 shRNA Plasmid (Human) - CHJ1302 from Cohesion Biosciences
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CHRNA10 miRNA 3'UTR clone - MiUTR1H-02141 from Creative biogene
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