| Gene Symbol |
TRIM23
|
| Entrez Gene |
373
|
| Alt Symbol |
ARD1, ARFD1, RNF46
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 23
|
| Other Description |
ADP-ribosylation factor domain protein 1, 64kDa|ADP-ribosylation factor domain-containing protein 1|ARF domain protein 1|E3 ubiquitin-protein ligase TRIM23|GTP-binding protein ARD-1|RING finger protein 46|tripartite motif protein TRIM23|tripartite motif-containing 23|tripartite motif-containing protein 23
|
| Swissprots |
P36406 Q9BZY4 Q9BZY5
|
| Accessions |
EAW51349 EAW51350 EAW51351 P36406 AF230397 AAG50176 AF230398 AAG50177 AF230399 AAG50178 AI679928 AK292814 BAF85503 BC022510 AAH22510 BI859501 DQ893646 ABM84572 DQ895584 ABM86510 L04510 AAA35940 XM_005248497 XP_005248554 NM_001656 NP_001647 NM_033227 NP_150230 NM_033228 NP_150231
|
| Function |
Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000269|PubMed:15684077}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:9671726}. Golgi apparatus membrane {ECO:0000269|PubMed:9671726}. Lysosome membrane {ECO:0000269|PubMed:9671726}. Note=Membrane-associated with the Golgi complex and lysosomal structures.
|