| Gene Symbol |
GSPT2
|
| Entrez Gene |
23708
|
| Alt Symbol |
ERF3B, GST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G1 to S phase transition 2
|
| Other Description |
eukaryotic peptide chain release factor GTP-binding subunit ERF3B|eukaryotic peptide chain release factor subunit 3b
|
| Swissprots |
Q9H909 Q9NVY0 Q9NY44 Q8IYD1
|
| Accessions |
EAW62898 Q8IYD1 AI191874 AJ251548 CAB91089 AK001303 BAA91612 AK023155 AK225671 AK298868 BAG60988 BC036077 AAH36077 BF514488 DA712335 DB173006 NM_018094 NP_060564
|
| Function |
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000269|PubMed:11524954, ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:17562865}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in IUCC stage II colorectal cancer (CRC). {ECO:0000269|PubMed:16721809}.
|
| Top Pathways |
mRNA surveillance pathway
|
![Western Blot: GSPT2 Overexpression Lysate (Adult Normal) [NBL1-11364] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GSPT2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3468_GSPT2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11364-img0002.jpg)