PDZD3

Gene Symbol PDZD3
Entrez Gene 79849
Alt Symbol IKEPP, NHERF4, PDZK2
Species Human
Gene Type protein-coding
Description PDZ domain containing 3
Other Description NHERF-4|Na(+)/H(+) exchange regulatory cofactor NHE-RF4|PDZ domain containing 2|PDZ domain-containing protein 2|PDZ domain-containing protein 3|intestinal and kidney enriched PDZ protein|intestinal and kidney-enriched PDZ protein|na/Pi cotransporter C-terminal-associated protein 2|naPi-Cap2|natrium-phosphate cotransporter IIa C-terminal-associated protein 2|sodium-hydrogen exchanger regulatory factor 4
Swissprots Q8NEX7 Q8NAW7 Q8N6R4 Q9H5Z3 Q86UT5
Accessions ACA06039 EAW67470 EAW67471 EAW67472 EAW67473 EAW67474 Q86UT5 AB094096 BAC76050 AK026409 BAB15474 AK091966 BAC03780 AK298333 BAG60582 AK315403 AY047359 AAL10686 BC029042 AAH29042 BX648391 DA381610 XM_011543000 XP_011541302 XM_011543001 XP_011541303 XM_011543002 XP_011541304 XM_011543003 XP_011541305 XM_011543004 XP_011541306 XM_011543005 XP_011541307 XM_011543006 XP_011541308 XM_011543007 XP_011541309 XM_011543008 XP_011541310 NM_001168468 NP_001161940 NM_024791 NP_079067 NR_033122
Function Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells.
Tissue Specificity Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. {ECO:0000269|PubMed:11950846}.

PDZK2 (D-16) - sc-82687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDZK2 (D-16): sc-82687. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

PDZK2 (H-208) - sc-368554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PDZK2 (W-14) - sc-82689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PDZD3 antibody - ab112545 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PDZD3 antibody (ab112545) at 1/1000 dilution + Human fetal kidney lysate

Anti-PDZD3 antibody - ab66146 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PDZD3 antibody (ab66146) at 1/500 dilutionLane 1 : PDZD3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-PDZD3 antibody - ab172672 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDZD3 antibody (ab172672) at 1 µg/mlLane 1 : PDZD3 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Rabbit IgG (H+L) HRP at 1/7500 dilutiondeveloped using the ECL technique

Anti-PDZD3 antibody - N-terminal - ab182507 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PDZD3 antibody - N-terminal (ab182507) at 1 µg/ml + HepG2 whole cell lysate at 10 µg

Anti-PDZD2 Antibody - LS-C196583 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa258-285, AP) - LS-C266012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa258-285, Biotin) - LS-C266014 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa258-285, APC) - LS-C266013 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa258-285, FITC) - LS-C266015 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa258-285, Azide-free, HRP) - LS-C266016 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa257-285) - LS-C323925 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa258-285, PE) - LS-C266017 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (aa105-154) - LS-C201888 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. PDZD3 antibody dilution 1.0 ug/ml.

Anti-PDZD3 Antibody (aa258-285) - LS-C158567 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PDZD3 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The PDZD3 antibody detected the PDZD3 protein (arrow).

Anti-PDZD3 Antibody (aa315-364) - LS-C201889 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. PDZD3 antibody dilution 1.0 ug/ml.

Anti-PDZD3 Antibody (aa119-435) - LS-C178569 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDZD3 Antibody (C-Terminus) IHC-plus™ - LS-B268 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PDZD3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B268 dilution 1:500.

IKEPP Antibody - NBP1-89846 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: IKEPP Antibody [NBP1-89846] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

IKEPP Antibody - H00079849-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: IKEPP Antibody [H00079849-B01] - analysis of PDZD3 expression in transfected 293T cell line by PDZD3 MaxPab polyclonal antibody (B01). Lane 1: PDZD3 transfected lysate (52.50 KDa). Lane 2: Non-transfected lysate.

IKEPP Antibody - H00079849-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

IKEPP Antibody - H00079849-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IKEPP Antibody [H00079849-D01P] - Analysis of PDZD3 expression in transfected 293T cell line by PDZD3 polyclonal antibody.Lane 1: PDZD3 transfected lysate(52.50 KDa).Lane 2: Non-transfected lysate.

IKEPP Antibody (1F2) - H00079849-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F2
Western Blot: IKEPP Antibody (1F2) [H00079849-M04] - Analysis of PDZD3 expression in transfected 293T cell line by PDZD3 monoclonal antibody (M04), clone 1F2. Lane 1: PDZD3 transfected lysatE (52.5 KDa). Lane 2: Non-transfected lysate.
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