TPM2

Gene Symbol	TPM2
Entrez Gene	7169
Alt Symbol	AMCD1, DA1, DA2B, HEL-S-273, NEM4, TMSB
Species	Human
Gene Type	protein-coding
Description	tropomyosin 2 (beta)
Other Description	epididymis secretory protein Li 273|nemaline myopathy type 4|tropomyosin beta chain
Swissprots	Q9UH67 P06468 P07951 Q5TCU7 Q13894 A6NM85 Q5TCU4 Q53FM4
Accessions	AAA51842 AAF17621 EAW58354 EAW58355 P07951 AA394062 AI360640 AI660199 AJ572605 AK130045 AK223258 BAD96978 AK294522 BAG57733 AK300249 BAG62015 AK304803 BAG65553 BC011776 AAH11776 BE294047 DQ892908 ABM83834 DQ896159 ABM87158 EU106177 ABU62930 F24979 FJ224304 ACI45996 M12125 AAA36773 M12126 AAA61229 M74817 AAA61230 M75165 AAB59509 X06825 CAA29971 XR_929320 XR_929321 XR_929322 XR_929323 XR_929324 XR_929325 NM_001301226 NP_001288155 NM_001301227 NP_001288156 NM_003289 NP_003280 NM_213674 NP_998839 NM_001145822
Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Present in primary breast cancer tissue, absent from normal breast tissue. {ECO:0000269|Ref.10}.
Top Pathways	Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TPM2 overexpression lysate - LY418786 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TPM2 293 Cell Lysate - 408780 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Tropomyosin β (h): 293T Lysate - sc-159612 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TPM2 Over-expression Lysate Product - GWB-DC4620 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

tropomyosin-2 Overexpression Lysate (Native) - NBP2-04458 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

tropomyosin-2 Overexpression Lysate (Native) - NBP2-10870 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human TPM2 Knockdown Stable Cell Line - CSC-DC016480 from Creative biogene Category Cell Line Species Human

TPM2 KO Cell Lysate-HEK293T - CLKO-0998 from Creative biogene Category Cell Lysate

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