TPM2

Gene Symbol TPM2
Entrez Gene 7169
Alt Symbol AMCD1, DA1, DA2B, HEL-S-273, NEM4, TMSB
Species Human
Gene Type protein-coding
Description tropomyosin 2 (beta)
Other Description epididymis secretory protein Li 273|nemaline myopathy type 4|tropomyosin beta chain
Swissprots Q9UH67 P06468 P07951 Q5TCU7 Q13894 A6NM85 Q5TCU4 Q53FM4
Accessions AAA51842 AAF17621 EAW58354 EAW58355 P07951 AA394062 AI360640 AI660199 AJ572605 AK130045 AK223258 BAD96978 AK294522 BAG57733 AK300249 BAG62015 AK304803 BAG65553 BC011776 AAH11776 BE294047 DQ892908 ABM83834 DQ896159 ABM87158 EU106177 ABU62930 F24979 FJ224304 ACI45996 M12125 AAA36773 M12126 AAA61229 M74817 AAA61230 M75165 AAB59509 X06825 CAA29971 XR_929320 XR_929321 XR_929322 XR_929323 XR_929324 XR_929325 NM_001301226 NP_001288155 NM_001301227 NP_001288156 NM_003289 NP_003280 NM_213674 NP_998839 NM_001145822
Function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytoskeleton.
Tissue Specificity Present in primary breast cancer tissue, absent from normal breast tissue. {ECO:0000269|Ref.10}.
Top Pathways Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes

Tropomyosin β siRNA (h) - sc-43478 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tropomyosin β shRNA Plasmid (h) - sc-43478-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tropomyosin β shRNA (h) Lentiviral Particles - sc-43478-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU146201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21869 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21869 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TPM2 siRNA (Human) - CRH4920 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPM2 - MBS828350 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TPM2(NM_213674.1) - SHL089706 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TPM2(NM_003289.3) - SHL089778 from Creative biogene

Category siRNA
Species Reactivities Human

Human TPM2 siRNA - orb265422 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPM2 shRNA Plasmid (Human) - CHH4920 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TPM2 miRNA 3'UTR clone - MiUTR1H-10670 from Creative biogene

Species Reactivities Human

TPM2 miRNA 3'UTR clone - MiUTR3H-02292 from Creative biogene

Species Reactivities Human
Search more