TJP2

Gene Symbol TJP2
Entrez Gene 9414
Alt Symbol C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2
Species Human
Gene Type protein-coding
Description tight junction protein 2
Other Description Friedreich ataxia region gene X104 (tight junction protein ZO-2)|tight junction protein ZO-2|zona occludens 2|zonula occludens protein 2
Swissprots Q5VXL0 A2A3H9 Q5VXL1 Q9UDY2 Q9UDY1 Q99839 B7Z7T6 B7Z2R8 F5H886 Q9UDY0 F5H301 Q8NI14 Q8N756 Q15883
Accessions AAC02527 AAD20387 AAD56218 AAD56219 EAW62476 EAW62477 EAW62478 EAW62479 EAW62480 Q9UDY2 AA724570 AF083892 AAC33121 AF083893 AAC33122 AF489824 AAM28524 AI738923 AK025185 AK295016 BAH11949 AK295034 BAH11954 AK302483 BAH13722 AK304447 BAH14190 AK307697 AK308564 AM392689 CAL37567 AM392712 CAL37590 AM392803 CAL37681 AM392967 CAL37845 BC027592 AAH27592 BC028426 CX865985 DA270962 DB090695 DB196171 DC325189 L27476 AAA61300 U84581 AAB41794 XM_005252314 XP_005252371 XM_006717324 XP_006717387 XM_011519204 XP_011517506 XM_011519205 XP_011517507 XM_011519206 XP_011517508 XM_011519207 XP_011517509 XM_011519208 XP_011517510 XM_011519209 XP_011517511 NM_001170414 NP_001163885 NM_001170415 NP_001163886 NM_001170416 NP_001163887 NM_001170630 NP_001164101 NM_004817 NP_004808 NM_201629 NP_963923
Function Plays a role in tight junctions and adherens junctions.
Subcellular Location Cell junction, adherens junction. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. {ECO:0000250}.
Tissue Specificity This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. {ECO:0000269|PubMed:11018256}.
Top Pathways Tight junction, Vibrio cholerae infection

ZO-2 CRISPR/Cas9 KO Plasmid (h) - sc-401395 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 HDR Plasmid (h) - sc-401395-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 Double Nickase Plasmid (h) - sc-401395-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 Double Nickase Plasmid (h2) - sc-401395-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 CRISPR Activation Plasmid (h) - sc-401395-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 CRISPR Activation Plasmid (h2) - sc-401395-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 Lentiviral Activation Particles (h) - sc-401395-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 Lentiviral Activation Particles (h2) - sc-401395-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZO-2 siRNA (h) - sc-29833 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZO-2 shRNA Plasmid (h) - sc-29833-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZO-2 shRNA (h) Lentiviral Particles - sc-29833-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tight Junction Protein 2 RNAi - H00009414-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Tight Junction Protein 2 RNAi - H00009414-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU075631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2280 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2279 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2281 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN21380 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21380 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06773 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06773

TJP2 siRNA (Human) - CRH6242 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TJP2 - MBS8204326 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TJP2 (NM_004817.3) - SHH427684 from Creative biogene

Category siRNA
Species Reactivities Human

Human TJP2 siRNA - orb266744 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TJP2 shRNA Plasmid (Human) - CHH6242 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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