Gene Symbol |
AKTIP
|
Entrez Gene |
64400
|
Alt Symbol |
FT1, FTS
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
AKT interacting protein
|
Other Description |
AKT-interacting protein|fused toes homolog|fused toes protein homolog
|
Swissprots |
Q53H38 Q9H8T0 Q503B1
|
Accessions |
CAD10180 EAW82803 EAW82804 EAW82805 EAW82806 EAW82807 EAW82808 EAW82809 Q9H8T0 AK023320 BAB14524 AK098222 AK222743 BAD96463 AK303503 BAG64536 AL133106 CAH56392 BC001134 AAH01134 BC095401 AAH95401 BG568989 BI545474 BM992149 CR457308 CAG33589 HQ448037 ADQ32518 XM_005256094 XP_005256151 XM_005256095 XP_005256152 XM_005256096 XP_005256153 XM_005256097 XP_005256154 XM_005256098 XP_005256155 NM_001012398 NP_001012398 NM_001308325 NP_001295254 NM_022476 NP_071921
|
Function |
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622}.
|
Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14749367}. Cell membrane {ECO:0000269|PubMed:14749367}; Peripheral membrane protein {ECO:0000269|PubMed:14749367}.
|