GRM6

Gene Symbol GRM6
Entrez Gene 2916
Alt Symbol CSNB1B, GPRC1F, MGLUR6, mGlu6
Species Human
Gene Type protein-coding
Description glutamate receptor, metabotropic 6
Other Description metabotropic glutamate receptor 6
Swissprots O15303
Accessions AAB82068 BAC05726 EAW53821 O15303 AJ245871 CAB65106 AJ245872 CAB65107 BC172277 AAI72277 BX647168 CAI46028 NM_000843 NP_000834
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:23452348}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Tissue Specificity Detected in melanocytes. {ECO:0000269|PubMed:23452348}.
Top Pathways Glutamatergic synapse, Neuroactive ligand-receptor interaction

mGluR-6 (C-18) - sc-47149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

mGluR-6 (H-50) - sc-99044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
mGluR-6 (H-50): sc-99044. Immunofluorescence staining of methanol-fixed HeLa cells showing golgi apparatus and cytoplasmic localization.

mGluR-6 (N-13) - sc-47150 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

mGluR-6 (N-17) - sc-47151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

mGluR-6 (C-16) - sc-47148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Metabotropic Glutamate Receptor 6+7 antibody, prediluted - ab15308 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15308 staining metabotropic Glutamate Receptor 6/7 in human brain by Immunohistochemistry (FFPE-sections).

Anti-Metabotropic Glutamate Receptor 6 antibody - ab83576 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Metabotropic Glutamate Receptor 6 antibody (ab83576) at 1 µg/ml + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Metabotropic Glutamate Receptor 6 antibody - ab90866 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Metabotropic Glutamate Receptor 6 antibody (ab90866) at 1 µg/ml + Human fetal small intestine lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Metabotropic Glutamate Receptor 6 antibody - ab116555 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Metabotropic Glutamate Receptor 6 antibody (ab116555) at 1/100 dilution + MDA-MB-435 cell lysate at 35 µg

Anti-Metabotropic Glutamate Receptor 6 antibody - ab55058 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55058 Metabotropic Glutamate Receptor 6 antibody at 1ug/ml.

Anti-Metabotropic Glutamate Receptor 6 antibody - C-terminal - ab154003 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Metabotropic Glutamate Receptor 6 antibody - C-terminal (ab154003) at 1/500 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-GRM6 / MGLUR6 Antibody (aa368-398, APC) - LS-C258073 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (aa368-398, AP) - LS-C258071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (aa368-398, FITC) - LS-C258074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (aa368-398, PE) - LS-C258075 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (C-Terminus, APC) - LS-C279564 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (C-Terminus, AP) - LS-C279563 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (C-Terminus, FITC) - LS-C279565 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (C-Terminus, PE) - LS-C279566 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (aa368-398) - LS-C321796 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRM6 / MGLUR6 Antibody (C-Terminus) - LS-C16550 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence: Detection of GluR6 in trapezoid body in mouse brain using LS-C16550 and anti-rabbit Cy3 conjugated secondary antibody (red color). DAPI was used to counterstain cell nuclei.

Anti-GRM6 / MGLUR6 Antibody (clone 1A11) - LS-C197361 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11
GRM6 monoclonal antibody (M01), clone 1A11. Western Blot analysis of GRM6 expression in human spleen.

Anti-GRM6 / MGLUR6 Antibody (aa369-398) - LS-C166686 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GRM6 Antibody western blot of MDA-MB435 cell line lysates (35 ug/lane). The GRM6 antibody detected the GRM6 protein (arrow).

Anti-GRM6 / MGLUR6 Antibody (Ala865) - LS-C176041 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of mGluR6 (A865) pAb in paraffin-embedded human brain tissue.

Anti-GRM6 / MGLUR6 Antibody (aa700-749) IHC-plus™ - LS-B157 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GRM6 / MGLUR6 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B157 concentration 5 ug/ml.
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