| Gene Symbol |
GRM6
|
| Entrez Gene |
2916
|
| Alt Symbol |
CSNB1B, GPRC1F, MGLUR6, mGlu6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 6
|
| Other Description |
metabotropic glutamate receptor 6
|
| Swissprots |
O15303
|
| Accessions |
AAB82068 BAC05726 EAW53821 O15303 AJ245871 CAB65106 AJ245872 CAB65107 BC172277 AAI72277 BX647168 CAI46028 NM_000843 NP_000834
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:23452348}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
|
| Tissue Specificity |
Detected in melanocytes. {ECO:0000269|PubMed:23452348}.
|
| Top Pathways |
Glutamatergic synapse, Neuroactive ligand-receptor interaction
|