GRM6

Gene Symbol	GRM6
Entrez Gene	2916
Alt Symbol	CSNB1B, GPRC1F, MGLUR6, mGlu6
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, metabotropic 6
Other Description	metabotropic glutamate receptor 6
Swissprots	O15303
Accessions	AAB82068 BAC05726 EAW53821 O15303 AJ245871 CAB65106 AJ245872 CAB65107 BC172277 AAI72277 BX647168 CAI46028 NM_000843 NP_000834
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:23452348}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Tissue Specificity	Detected in melanocytes. {ECO:0000269|PubMed:23452348}.
Top Pathways	Glutamatergic synapse, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Metabotropic Glutamate Receptor 6 protein fragment - ab158590 from Abcam Category Protein Source Wheat germ Species Human

GRM6 / MGLUR6 Antibody Blocking Peptide - LS-E2660 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRM6 / MGLUR6 Antibody Blocking Peptide - LS-E29020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GRM6 / MGLUR6 Antibody Blocking Peptide - LS-E28982 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GRM6 / MGLUR6 Antibody Blocking Peptide - LS-E11443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRM6 / MGLUR6 Antibody Blocking Peptide - LS-E11131 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRM6 / MGLUR6 Antibody Blocking Peptide - LS-E21217 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

mGluR6 Blocking Peptide - NB300-189PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Rat

Recombinant Human mGluR6 Protein - H00002916-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GRM6-Antibody-Center-Blocking-peptide - BP13735c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRM6 peptide - orb217370 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

GRM6 Blocking Peptide - 33R-1198 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRM6 Blocking Peptide - 33R-4175 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRM6 Blocking Peptide - 33R-2416 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

mGLUR6 Blocking Peptide - abx062701 from Abbexa Category Peptide Species Human, Mouse, Rat

mGluR6 / GRM6 - H00002916-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

mGluR6 / GRM6 - H00002916-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human GRM6 - GRM6-679H from Creative Biomart Category Protein Source Mammalian Cells Species Human

ChemiSCREEN™ Membrane Preparation Recombinant Human mGlu 6 Metabotropic Glutamate Receptor - HTS149M from EMD Millipore Prices $905.00 Sizes 200 units Species Human

mGLUR6 Blocking Peptide - CBP1507 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

mGluR-6 (A865) Peptide - BS1146P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Metabotropic-Glutamate-Receptor-6-GPRC1F-Antibody-C-term-Blocking-peptide - BP1642a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRM6 Peptide, Human - M34GP06678H from Creative Peptides Category Peptide Source Synthetic. Species Human

mGluR6 Blocking Peptide - 214-20001 from RayBiotech Category Peptide Prices $158.00 Sizes 50 µl

mGluR6 Recombinant Protein Antigen - NBP2-58374PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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