GRM6

Gene Symbol GRM6
Entrez Gene 2916
Alt Symbol CSNB1B, GPRC1F, MGLUR6, mGlu6
Species Human
Gene Type protein-coding
Description glutamate receptor, metabotropic 6
Other Description metabotropic glutamate receptor 6
Swissprots O15303
Accessions AAB82068 BAC05726 EAW53821 O15303 AJ245871 CAB65106 AJ245872 CAB65107 BC172277 AAI72277 BX647168 CAI46028 NM_000843 NP_000834
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:23452348}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Golgi apparatus membrane {ECO:0000269|PubMed:17405131}; Multi-pass membrane protein {ECO:0000269|PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Tissue Specificity Detected in melanocytes. {ECO:0000269|PubMed:23452348}.
Top Pathways Glutamatergic synapse, Neuroactive ligand-receptor interaction

mGluR-6 CRISPR/Cas9 KO Plasmid (h) - sc-405380 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 HDR Plasmid (h) - sc-405380-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 Double Nickase Plasmid (h) - sc-405380-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 Double Nickase Plasmid (h2) - sc-405380-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 CRISPR Activation Plasmid (h) - sc-405380-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 CRISPR Activation Plasmid (h2) - sc-405380-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 Lentiviral Activation Particles (h) - sc-405380-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 Lentiviral Activation Particles (h2) - sc-405380-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mGluR-6 siRNA (h) - sc-61036 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mGluR-6 shRNA Plasmid (h) - sc-61036-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mGluR-6 shRNA (h) Lentiviral Particles - sc-61036-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU140761 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1827 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1827 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GRM6 siRNA (Human) - CRH1969 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

mGluR6 RNAi - H00002916-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

GRM6 - MBS8205134 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GRM6 (NM_000843.3) - SHH308150 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GRM6(NM_000843.3) - SHH105761 from Creative biogene

Category siRNA
Species Reactivities Human

Human GRM6 siRNA - orb262471 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRM6 shRNA Plasmid (Human) - CHH1969 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GRM6 miRNA 3'UTR clone - MiUTR1H-04292 from Creative biogene

Species Reactivities Human
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