SKP2

Gene Symbol	SKP2
Entrez Gene	6502
Alt Symbol	FBL1, FBXL1, FLB1, p45
Species	Human
Gene Type	protein-coding
Description	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Other Description	CDK2/cyclin A-associated protein p45|F-box/LRR-repeat protein 1|S-phase kinase-associated protein 2|S-phase kinase-associated protein 2 (p45)|p45skp2
Swissprots	Q8TDZ1 Q13309 A8K5E0 Q8TDZ0 Q9BV69 B4DJT4
Accessions	AAY87142 EAW55934 EAW55935 EAW55936 EAW55937 EAW55938 Q13309 AB050979 BAB87200 AB050980 BAB87201 AB050981 BAB87202 AK026224 AK291255 BAF83944 AK295152 BAG58168 AK296223 BAG58946 AY029177 AAK31593 BC001441 AAH01441 BC007441 AAH07441 CA415778 DA223617 U33761 AAC50242 XM_011514081 XP_011512383 XM_011514082 XP_011512384 XM_011514083 XP_011512385 NM_001243120 NP_001230049 NM_005983 NP_005974 NM_032637 NP_116026
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. {ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|Pu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SKP2 ELISA Kit (Cell-Based ELISA) - LS-F2310 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human SKP2 ELISA Kit (Sandwich ELISA) - LS-F9250 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.156-10 ng/ml

Human SKP2 ELISA Kit (Sandwich ELISA) - LS-F12609 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

S-Phase Kinase Associated Protein 2 (SKP2), Human, ELISA Kit - SEC847Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

S-phase kinase-associated protein 2, SKP2, Human, ELISA Kit - E9870h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

SKP2/p45 Colorimetric Cell-Based ELISA Kit - CB5635 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

S-Phase Kinase Associated Protein 2 (SKP2), ELISA Kit - MBS2020011 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.061ng/mL. Range 0.156-10ng/mL

ELISA Kit for S-Phase Kinase Associated Protein 2 (SKP2) - SEC847Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for S-Phase Kinase Associated Protein 2 (SKP2) - SEC847Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse SKP2 ELISA Kit (Custom ELISA) - LS-F20602 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human SKP2 ELISA Kit - abx153100 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

S-Phase Kinase Associated Protein 2 (SKP2), Human, ELISA Kit - DL-SKP2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

SKP2/p45 ELISA Kit - DEIA-XYA1623 from Creative Diagnostics Category ELISA Kit

Human SKP2 ELISA Kit - orb370750 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.156-10ng/mL Detection low threshold: 0.061ng/mL

Human SKP2 ELISA Kit - abx571727 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

SKP2 - EKH5048 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

SKP2 ELISA Kit (Human) : 96 Wells (OKEH02026) - OKEH02026 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.089 ng/mL Range 0.156 - 10 ng/mL

Human SKP2 ELISA Kit - E034060 from Biobool Category ELISA Kit Sensitivity Typically less than 0.061ng/mL.

Human S-phase kinase-associated protein 2 ELISA Kit - EK5058 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.089ng/mL Range 0.156-10 ng/mL

Human S-phase kinase-associated protein 2 (SKP2) ELISA Kit - AE19426HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

S-Phase Kinase Associated Protein 2 (SKP2), ELISA Kit - MBS455518 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.061ng/mL Range 0.156-10ng/mL

S-phase kinase-associated protein 2, ELISA Kit - MBS2886660 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

S-phase kinase-associated protein 2, ELISA Kit - MBS9428884 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.089ng/mL Range 0.156-10 ng/mL

S-Phase Kinase Associated Protein 2 (SKP2), ELISA Kit - MBS9381189 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SKP2 ELISA Kit (Sandwich ELISA) - LS-F33652 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

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