SKP2

Gene Symbol	SKP2
Entrez Gene	6502
Alt Symbol	FBL1, FBXL1, FLB1, p45
Species	Human
Gene Type	protein-coding
Description	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Other Description	CDK2/cyclin A-associated protein p45|F-box/LRR-repeat protein 1|S-phase kinase-associated protein 2|S-phase kinase-associated protein 2 (p45)|p45skp2
Swissprots	Q8TDZ1 Q13309 A8K5E0 Q8TDZ0 Q9BV69 B4DJT4
Accessions	AAY87142 EAW55934 EAW55935 EAW55936 EAW55937 EAW55938 Q13309 AB050979 BAB87200 AB050980 BAB87201 AB050981 BAB87202 AK026224 AK291255 BAF83944 AK295152 BAG58168 AK296223 BAG58946 AY029177 AAK31593 BC001441 AAH01441 BC007441 AAH07441 CA415778 DA223617 U33761 AAC50242 XM_011514081 XP_011512383 XM_011514082 XP_011512384 XM_011514083 XP_011512385 NM_001243120 NP_001230049 NM_005983 NP_005974 NM_032637 NP_116026
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. {ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|Pu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SKP2 full length protein - ab114385 from Abcam Category Protein Source Wheat germ Species Human

Human SKP2 peptide - ab26153 from Abcam Category Peptide

Human SKP2 peptide - ab95419 from Abcam Category Peptide

Human SKP2 protein fragment - ab114386 from Abcam Category Protein Source Wheat germ Species Human

SKP2 Antibody Blocking Peptide - LS-E9605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Skp2 Protein - H00006502-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Skp2 Protein - H00006502-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SKP2-Antibody-Center-Blocking-Peptide - BP8503c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human S-Phase Kinase-Associated Protein 2 protein - orb90267 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

Human SKP2 protein - orb246551 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SKP2 Blocking Peptide - abx063263 from Abbexa Category Peptide Species Human, Bovine, Pig

SKP2 / FBXL1 - H00006502-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SKP2 / FBXL1 - H00006502-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SKP2 / FBXL1 - H00006502-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SKP2 / FBXL1 - H00006502-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SKP2 fusion protein - ag7137 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SKP2 fusion protein - ag6826 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SKP2 - BP000727-ENZ-376 from Syd Labs Category Protein Prices $200.00, $295.00, $490.00 Sizes 2 µg, 5 µg, 10 µg Source E. coli-derived. Species Human

Recombinant Human S-Phase Kinase-Associated Protein 2 - GWB-5A131D from Genway Biotech Category Protein Prices $75.00, $165.00, $2,860.00 Sizes 5 μg, 20 μg, 1000 μg Species Human

Recombinant Human S-Phase Kinase-Associated Protein 2 (p45), GST-tagged - SKP2-1465H from Creative Biomart Category Protein Source Human

Recombinant Human SKP2 protein, His/T7-tagged - SKP2-36H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human S-phase Kinase-associated Protein 2 (p45) - SKP2-684H from Creative Biomart Category Protein Source E. coli.

Recombinant Human SKP2 - SKP2-31723TH from Creative Biomart Category Protein Source Wheat germ

SKP2 Human - JNV-712 from Reagent Proteins Category Protein Prices $364.00, $2,590.00 Sizes 5.00 µg, 10.00 µg Source E.coli Species Human

Recombinant S-Phase Kinase Associated Protein 2 (SKP2) - RPC847Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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