SKP2

Gene Symbol	SKP2
Entrez Gene	6502
Alt Symbol	FBL1, FBXL1, FLB1, p45
Species	Human
Gene Type	protein-coding
Description	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Other Description	CDK2/cyclin A-associated protein p45|F-box/LRR-repeat protein 1|S-phase kinase-associated protein 2|S-phase kinase-associated protein 2 (p45)|p45skp2
Swissprots	Q8TDZ1 Q13309 A8K5E0 Q8TDZ0 Q9BV69 B4DJT4
Accessions	AAY87142 EAW55934 EAW55935 EAW55936 EAW55937 EAW55938 Q13309 AB050979 BAB87200 AB050980 BAB87201 AB050981 BAB87202 AK026224 AK291255 BAF83944 AK295152 BAG58168 AK296223 BAG58946 AY029177 AAK31593 BC001441 AAH01441 BC007441 AAH07441 CA415778 DA223617 U33761 AAC50242 XM_011514081 XP_011512383 XM_011514082 XP_011512384 XM_011514083 XP_011512385 NM_001243120 NP_001230049 NM_005983 NP_005974 NM_032637 NP_116026
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. {ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|Pu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Skp2 siRNA I - 7753 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Skp2 siRNA II - 7756 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (534)

Skp2 p45 CRISPR/Cas9 KO Plasmid (h) - sc-400534 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 HDR Plasmid (h) - sc-400534-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 Double Nickase Plasmid (h) - sc-400534-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 Double Nickase Plasmid (h2) - sc-400534-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 CRISPR Activation Plasmid (h) - sc-400534-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 CRISPR Activation Plasmid (h2) - sc-400534-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 Lentiviral Activation Particles (h) - sc-400534-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 Lentiviral Activation Particles (h2) - sc-400534-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp2 p45 siRNA (h) - sc-36499 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Skp2 p45 shRNA Plasmid (h) - sc-36499-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Skp2 p45 shRNA (h) Lentiviral Particles - sc-36499-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Skp2 RNAi - H00006502-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Skp2 RNAi - H00006502-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU094381 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19385 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19385 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SKP2 siRNA (Human) - CRH4397 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SKP2 - MBS8217993 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SKP (NM_005983.3) - SHH408068 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SKP2(NM_005983.3) - SHR193164 from Creative biogene Category siRNA Species Reactivities Human

SKP2 shRNA Plasmid (Human) - CHH4397 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SKP2 miRNA 3'UTR clone - MiUTR3H-04118 from Creative biogene Species Reactivities Human

SKP2 miRNA 3'UTR clone - MiUTR3H-04119 from Creative biogene Species Reactivities Human

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