| Gene Symbol |
PARL
|
| Entrez Gene |
55486
|
| Alt Symbol |
PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
presenilin associated, rhomboid-like
|
| Other Description |
mitochondrial intramembrane cleaving protease PARL|mitochondrial intramembrane-cleaving protease PARL|presenilins-associated rhomboid-like protein, mitochondrial|rhomboid 7 homolog 1
|
| Swissprots |
Q9BTJ6 Q9P1E3 Q96CQ4 Q9H300
|
| Accessions |
CAD67638 CAI93557 CBF58125 CBF58133 CBF68751 CBF68759 CBU83560 CBU83568 CBU93625 CBU93633 EAW78311 EAW78312 Q9H300 AF197937 AAG28519 AK024765 BC003653 AAH03653 BC014058 AAH14058 CA417847 CB122278 DQ893442 ABM84368 DQ896749 ABM87748 XM_005247582 XP_005247639 XM_005247584 XP_005247641 XM_005247587 XP_005247644 NM_001037639 NP_001032728 NM_018622 NP_061092 NM_001037640
|
| Function |
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. {ECO:0000250, ECO:0000269|PubMed:14732705, ECO:0000269|PubMed:17116872}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:17116872}; Multi-pass membrane protein {ECO:0000269|PubMed:17116872}.
|
![Western Blot: PARL Overexpression Lysate (Adult Normal) [NBL1-14107] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PARL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19618_PARL%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14107-img0002.jpg)