PARL

Gene Symbol PARL
Entrez Gene 55486
Alt Symbol PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Species Human
Gene Type protein-coding
Description presenilin associated, rhomboid-like
Other Description mitochondrial intramembrane cleaving protease PARL|mitochondrial intramembrane-cleaving protease PARL|presenilins-associated rhomboid-like protein, mitochondrial|rhomboid 7 homolog 1
Swissprots Q9BTJ6 Q9P1E3 Q96CQ4 Q9H300
Accessions CAD67638 CAI93557 CBF58125 CBF58133 CBF68751 CBF68759 CBU83560 CBU83568 CBU93625 CBU93633 EAW78311 EAW78312 Q9H300 AF197937 AAG28519 AK024765 BC003653 AAH03653 BC014058 AAH14058 CA417847 CB122278 DQ893442 ABM84368 DQ896749 ABM87748 XM_005247582 XP_005247639 XM_005247584 XP_005247641 XM_005247587 XP_005247644 NM_001037639 NP_001032728 NM_018622 NP_061092 NM_001037640
Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. {ECO:0000250, ECO:0000269|PubMed:14732705, ECO:0000269|PubMed:17116872}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:17116872}; Multi-pass membrane protein {ECO:0000269|PubMed:17116872}.

PARL CRISPR/Cas9 KO Plasmid (h) - sc-403965 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL HDR Plasmid (h) - sc-403965-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL Double Nickase Plasmid (h) - sc-403965-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL Double Nickase Plasmid (h2) - sc-403965-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL CRISPR Activation Plasmid (h) - sc-403965-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL CRISPR Activation Plasmid (h2) - sc-403965-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL Lentiviral Activation Particles (h) - sc-403965-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL Lentiviral Activation Particles (h2) - sc-403965-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARL siRNA (h) - sc-61295 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARL shRNA Plasmid (h) - sc-61295-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARL shRNA (h) Lentiviral Particles - sc-61295-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU115721 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16339 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16339 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00648 from Sigma-Aldrich

Category miRNA

PARL siRNA (Human) - CRJ0708 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PARL (NM_018622.5) - SHH370764 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PARL(NM_018622.5) - SHR088220 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PARL(NM_001037639.1) - SHR088238 from Creative biogene

Category siRNA
Species Reactivities Human

PARL shRNA Plasmid (Human) - CHJ0708 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PARL miRNA 3'UTR clone - MiUTR1H-07516 from Creative biogene

Species Reactivities Human

PARL miRNA 3'UTR clone - MiUTR3H-09512 from Creative biogene

Species Reactivities Human
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