TOR1A

Gene Symbol	TOR1A
Entrez Gene	1861
Alt Symbol	DQ2, DYT1
Species	Human
Gene Type	protein-coding
Description	torsin family 1, member A (torsin A)
Other Description	dystonia 1 protein\|dystonia 1, torsion (autosomal dominant; torsin A)\|torsin ATPase 1\|torsin ATPase-1A\|torsin family 1 member A\|torsin-1A
Swissprots	B2RB58 O14656 Q53Y64 Q96CA0
Accessions	EAW87907 EAW87908 O14656 AF007871 AAC51732 AK056062 BAG51613 AK075343 AK130769 AK294677 BAG57840 AK314505 BAG37105 AU098588 BC000674 AAH00674 BC014484 AAH14484 BT006931 AAP35577 BU790507 DQ892657 ABM83583 DQ895897 ABM86823 XR_929731 NM_000113 NP_000104
Function	Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function
Subcellular Location	Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. {ECO:0000250}.
Tissue Specificity	Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord. {ECO:0000269\|PubMed:10640617, ECO:0000269\|PubMed:14970196, ECO:0000269\|PubMed:15147511}.

TorsinA (D-M2A8) Mouse mAb - 2150 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Mouse
Clonality	Monoclonal
Clone	D-M2A8

Western blot analysis of extracts from SH-SY5Y and U87MG cells, using TorsinA (D-M2A8) Mouse mAb.

TorsinA (D-7) - sc-373915 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TorsinA (D-7): sc-373915. Western blot analysis of TorsinA expression in MDA-MB-231 whole cell lysate.

TorsinA (H-85) - sc-33606 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

TorsinA (H-85): sc-33606. Western blot analysis of TorsinA expression in NIH/3T3 whole cell lysate.

TorsinA (S-20) - sc-19483 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TorsinA (S-20): sc-19483. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

TorsinA (V-20) - sc-19482 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Torsin A antibody - ab34540 from Abcam

Prices	$401.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Torsin A antibody (ab34540) at 1 µg/mlLane 1 : MarkerLane 2 : Mouse Brain at 10 µgLane 3 : Testis (Mouse) Whole Cell Lysate - normal tissue at 10 µgLane 4 : Mouse Heart Mouse Tissue Lysate at 10 µgLane 5 : Skeletal Muscle (Mouse) Tissue Lysate (ab29711) at 10 µgLane 6 : Mouse Fetal lysate - 14 Days old Tissue Lysate at 10 µgLane 7 : Brain (Mouse) Tissue Lysate - normal tissue, 0 days old (ab7188) at 10 µgLane 8 : Mouse Embryonic Fibroblast 1 at 10 µgLane 9 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell Lysate (ab7179) at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-Torsin A antibody [EP2569Y] - ab76133 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2569Y

All lanes : Anti-Torsin A antibody [EP2569Y] (ab76133) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysatesLane 2 : 293T cell lysatesLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-TOR1A / Torsin A Antibody - LS-C39761 from LifeSpan Bioscience

Prices	$530.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal

Anti-TOR1A / Torsin A Antibody (aa40-90) - LS-C203286 from LifeSpan Bioscience

Prices	$245.00
Sizes	40 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (aa266-295, AP) - LS-C271970 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (aa266-295, APC) - LS-C271971 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (aa266-295, Biotin) - LS-C271972 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (aa266-295, FITC) - LS-C271973 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (aa266-295, Azide-free, HRP) - LS-C271974 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (aa266-295, PE) - LS-C271975 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody - LS-C159501 from LifeSpan Bioscience

Prices	$295.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal

DYT1 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The DYT1 antibody detected the DYT1 protein (arrow).

Anti-TOR1A / Torsin A Antibody (aa266-295) - LS-C325869 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOR1A / Torsin A Antibody (C-Terminus, clone EP2569Y) - LS-C105399 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2569Y

Western blot analysis on (A) SH-SY5Y and (B) 293T cell lysates using anti-TorsinA antibody (LS-C105399), dilution 1:1000.

Anti-TOR1A / Torsin A Antibody (aa201-250) - LS-C146485 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

TOR1A / Torsin A antibody LS-C146485 Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.

Anti-TOR1A / Torsin A Antibody - LS-C192759 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts of MCF-7 cell lines, using TOR1A antibody.

Anti-TOR1A / Torsin A Antibody (aa267-295) - LS-C157243 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

TOR1A Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The TOR1A antibody detected the TOR1A protein (arrow).

Anti-TOR1A / Torsin A Antibody - LS-C331866 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using TOR1A antibody.

Torsin A Antibody - NBP2-20685 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Torsin A Antibody [NBP2-20685] - Sample (30 ug of whole cell lysate) A: U87-MG 10% SDS PAGE gel, diluted at 1:1000.

Anti-TOR1A antibody produced in rabbit - SAB2701146 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-TOR1A: <B>Cat. No. SAB2701146</B>: Western Blot analysis of TOR1A in extracts from <B>Lanes</B><BR/>A. U87-MG using <B>Cat. No. SAB2701146</B> at a 1:1000 dilution.

MONOCLONAL ANTI-DYT1 antibody produced in mouse - SAB1305517 from Sigma-Aldrich

Prices	$326.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	583CT1.1.3

<B>Immunoblotting</B><BR/>Monoclonal Anti-DYT1: <B>Cat. No. SAB1305517</B>: Monoclonal Anti-DYT1 western blot analysis in ZR-75-1 cell line lysates (35 μg/lane).

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