| Gene Symbol |
TRAF6
|
| Entrez Gene |
7189
|
| Alt Symbol |
MGC:3310, RNF85
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer
|
| Swissprots |
A8KAB3 Q9Y4K3 Q8NEH5 A6NKI7 D3DR16
|
| Accessions |
AAO38054 EAW68119 EAW68120 EAW68121 EAW68122 Q9Y4K3 AK128396 AK292978 BAF85667 BC031052 AAH31052 BI463192 BQ187062 DA855021 DQ891209 ABM82135 DQ894392 ABM85318 U78798 AAB38751 NM_004620 NP_004611 NM_145803 NP_665802
|
| Function |
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:1105
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18093978}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|
| Top Pathways |
Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection
|