TRAF6
| Gene Symbol | TRAF6 |
|---|---|
| Entrez Gene | 7189 |
| Alt Symbol | MGC:3310, RNF85 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer |
| Swissprots | A8KAB3 Q9Y4K3 Q8NEH5 A6NKI7 D3DR16 |
| Accessions | AAO38054 EAW68119 EAW68120 EAW68121 EAW68122 Q9Y4K3 AK128396 AK292978 BAF85667 BC031052 AAH31052 BI463192 BQ187062 DA855021 DQ891209 ABM82135 DQ894392 ABM85318 U78798 AAB38751 NM_004620 NP_004611 NM_145803 NP_665802 |
| Function | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:1105 |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18093978}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Top Pathways | Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection |
TRAF6 CRISPR/Cas9 KO Plasmid (h) - sc-400117 from Santa Cruz Biotechnology
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TRAF6 HDR Plasmid (h) - sc-400117-HDR from Santa Cruz Biotechnology
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TRAF6 Double Nickase Plasmid (h) - sc-400117-NIC from Santa Cruz Biotechnology
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TRAF6 Double Nickase Plasmid (h2) - sc-400117-NIC-2 from Santa Cruz Biotechnology
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TRAF6 CRISPR Activation Plasmid (h) - sc-400117-ACT from Santa Cruz Biotechnology
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TRAF6 CRISPR Activation Plasmid (h2) - sc-400117-ACT-2 from Santa Cruz Biotechnology
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TRAF6 Lentiviral Activation Particles (h) - sc-400117-LAC from Santa Cruz Biotechnology
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TRAF6 Lentiviral Activation Particles (h2) - sc-400117-LAC-2 from Santa Cruz Biotechnology
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TRAF6 siRNA (h) - sc-36717 from Santa Cruz Biotechnology
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TRAF6 shRNA Plasmid (h) - sc-36717-SH from Santa Cruz Biotechnology
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TRAF6 shRNA (h) Lentiviral Particles - sc-36717-V from Santa Cruz Biotechnology
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TRAF6 siRNA (h2) - sc-44329 from Santa Cruz Biotechnology
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TRAF6 shRNA Plasmid (h2) - sc-44329-SH from Santa Cruz Biotechnology
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TRAF6 shRNA (h2) Lentiviral Particles - sc-44329-V from Santa Cruz Biotechnology
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TRAF-6 RNAi - H00007189-R01V from Novus Biologicals
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TRAF-6 RNAi - H00007189-R02 from Novus Biologicals
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TRAF-6 RNAi - H00007189-R01 from Novus Biologicals
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MISSION® esiRNA - EHU147511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2235 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2235 from Sigma-Aldrich
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TRAF6 siRNA (Human) - CRH4938 from Cohesion Biosciences
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TRAF6 - MBS8238492 from MyBioSource
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TRAF6 shRNA Plasmid (Human) - CHH4938 from Cohesion Biosciences
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TRAF6 miRNA 3'UTR clone - MiUTR3H-04905 from Creative biogene
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TRAF6 miRNA 3'UTR clone - MiUTR3H-04906 from Creative biogene
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