| Gene Symbol |
HCFC1R1
|
| Entrez Gene |
54985
|
| Alt Symbol |
HPIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
host cell factor C1 regulator 1 (XPO1 dependent)
|
| Other Description |
HCF-1 beta-propeller-interacting protein|host cell factor C1 regulator 1
|
| Swissprots |
Q68EN7 D3DUA7 Q9NWW0
|
| Accessions |
CAV30734 CAV30735 CAV30736 EAW85424 EAW85425 EAW85426 EAW85427 Q9NWW0 AK000575 BAA91265 AK293768 BAG57184 AY116892 AAM49798 BC064026 AAH64026 BC065514 BC080178 AAH80178 BM790570 BM925785 BU623445 BU633901 CN427571 CR457245 CAG33526 HQ447528 ADQ32014 XM_011522558 XP_011520860 XM_011522559 XP_011520861 NM_001002017 NP_001002017 NM_001002018 NP_001002018 NM_001288665 NP_001275594 NM_001288666 NP_001275595 NM_001288667 NP_001275596 NM_001288668 NP_001275597 NM_001308070 NP_001294999 NM_017885 NP_060355
|
| Function |
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. {ECO:0000269|PubMed:12235138}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus {ECO:0000269|PubMed:12235138}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12235138}.
|