ALKBH5

Gene Symbol	ALKBH5
Entrez Gene	54890
Alt Symbol	ABH5, OFOXD, OFOXD1
Species	Human
Gene Type	protein-coding
Description	AlkB family member 5, RNA demethylase
Other Description	RNA demethylase ALKBH5|alkB, alkylation repair homolog 5|alkylated DNA repair protein alkB homolog 5|alpha-ketoglutarate-dependent dioxygenase alkB homolog 5|oxoglutarate and iron-dependent oxygenase domain containing|probable alpha-ketoglutarate-dependent dioxygenase ABH5
Swissprots	D3DXC6 Q6P6C2 Q9NXD6 B4DVJ4
Accessions	EAW55661 EAW55662 Q6P6C2 AK000129 AK000315 BAA91078 AK025817 AK301107 BAG62706 AK311161 AK311511 AL137263 BC062339 AAH62339 BI823385 BU740432 NM_017758 NP_060228
Function	Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)- methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736}.
Tissue Specificity	Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary. {ECO:0000269|PubMed:17979886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ALKBH5 293T Cell Transient Overexpression Lysate(Denatured) - H00054890-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ALKBH5 overexpression lysate - LY402613 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ALKBH5 293 Cell Lysate - 402280 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Escherichia coli

ALKBH5 Overexpression Lysate (Native) - NBL1-07476 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ALKBH5 Over-expression Lysate Product - GWB-B42CB8 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ALKBH5 Overexpression Lysate (Denatured) - H00054890-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ALKBH5 Overexpression Lysate (Denatured) - H00054890-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human ALKBH5 Knockdown Stable Cell Line - CSC-DC000515 from Creative biogene Category Cell Line Species Human

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