| Gene Symbol |
ALKBH5
|
| Entrez Gene |
54890
|
| Alt Symbol |
ABH5, OFOXD, OFOXD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
AlkB family member 5, RNA demethylase
|
| Other Description |
RNA demethylase ALKBH5|alkB, alkylation repair homolog 5|alkylated DNA repair protein alkB homolog 5|alpha-ketoglutarate-dependent dioxygenase alkB homolog 5|oxoglutarate and iron-dependent oxygenase domain containing|probable alpha-ketoglutarate-dependent dioxygenase ABH5
|
| Swissprots |
D3DXC6 Q6P6C2 Q9NXD6 B4DVJ4
|
| Accessions |
EAW55661 EAW55662 Q6P6C2 AK000129 AK000315 BAA91078 AK025817 AK301107 BAG62706 AK311161 AK311511 AL137263 BC062339 AAH62339 BI823385 BU740432 NM_017758 NP_060228
|
| Function |
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)- methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736}.
|
| Tissue Specificity |
Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary. {ECO:0000269|PubMed:17979886}.
|