ALKBH5

Gene Symbol	ALKBH5
Entrez Gene	54890
Alt Symbol	ABH5, OFOXD, OFOXD1
Species	Human
Gene Type	protein-coding
Description	AlkB family member 5, RNA demethylase
Other Description	RNA demethylase ALKBH5|alkB, alkylation repair homolog 5|alkylated DNA repair protein alkB homolog 5|alpha-ketoglutarate-dependent dioxygenase alkB homolog 5|oxoglutarate and iron-dependent oxygenase domain containing|probable alpha-ketoglutarate-dependent dioxygenase ABH5
Swissprots	D3DXC6 Q6P6C2 Q9NXD6 B4DVJ4
Accessions	EAW55661 EAW55662 Q6P6C2 AK000129 AK000315 BAA91078 AK025817 AK301107 BAG62706 AK311161 AK311511 AL137263 BC062339 AAH62339 BI823385 BU740432 NM_017758 NP_060228
Function	Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)- methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736}.
Tissue Specificity	Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary. {ECO:0000269|PubMed:17979886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALKBH5 full length protein - ab162879 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

ALKBH5 Antibody Blocking Peptide - LS-E5858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ALKBH5 Protein - H00054890-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ALKBH5-Antibody-Center-Blocking-Peptide - BP18410c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALKBH5 / OFOXD1 - H00054890-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ALKBH5 fusion protein - ag10490 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ALKBH5 fusion protein - Ag10516 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH5(ALKBH5 - CSB-YP744062HU CSB-EP744062HU CSB-BP744062HU CSB-MP744062HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Probable alpha-ketoglutarate-dependent dioxygenase ABH5 (ALKBH5), Recombinant Protein - MBS1355460 from MyBioSource Category Protein Prices $1,165.00, $1,165.00, $1,395.00, $1,395.00, $1,865.00, $1,865.00, $2,330.00, $2,330.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ALKBH5 Recombinant Protein Antigen - NBP1-82188PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ALKBH5 Peptide, Human - M34GP00515H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant ALKBH5 protein - 31589 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant Human ALKBH5 Protein, Flag-tagged - ALKBH5-32H from Creative Biomart Category Protein Source Insect Cells Species Human

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