ALKBH5

Gene Symbol ALKBH5
Entrez Gene 54890
Alt Symbol ABH5, OFOXD, OFOXD1
Species Human
Gene Type protein-coding
Description AlkB family member 5, RNA demethylase
Other Description RNA demethylase ALKBH5|alkB, alkylation repair homolog 5|alkylated DNA repair protein alkB homolog 5|alpha-ketoglutarate-dependent dioxygenase alkB homolog 5|oxoglutarate and iron-dependent oxygenase domain containing|probable alpha-ketoglutarate-dependent dioxygenase ABH5
Swissprots D3DXC6 Q6P6C2 Q9NXD6 B4DVJ4
Accessions EAW55661 EAW55662 Q6P6C2 AK000129 AK000315 BAA91078 AK025817 AK301107 BAG62706 AK311161 AK311511 AL137263 BC062339 AAH62339 BI823385 BU740432 NM_017758 NP_060228
Function Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)- methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178}.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736}.
Tissue Specificity Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary. {ECO:0000269|PubMed:17979886}.

ALKBH5 CRISPR/Cas9 KO Plasmid (h) - sc-412371 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 HDR Plasmid (h) - sc-412371-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 Double Nickase Plasmid (h) - sc-412371-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 Double Nickase Plasmid (h2) - sc-412371-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 CRISPR Activation Plasmid (h) - sc-412371-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 CRISPR Activation Plasmid (h2) - sc-412371-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 Lentiviral Activation Particles (h) - sc-412371-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 Lentiviral Activation Particles (h2) - sc-412371-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH5 siRNA (h) - sc-93856 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALKBH5 shRNA Plasmid (h) - sc-93856-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALKBH5 shRNA (h) Lentiviral Particles - sc-93856-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU021751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3070 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3070 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10105 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10105

ALKBH5 siRNA (Human) - CRJ0300 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALKBH5 - MBS8217361 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ALKBH5 (NM_017758.3) - SHH235258 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ALKBH5(NM_017758.3) - SHG054433 from Creative biogene

Category siRNA
Species Reactivities Human

Human ALKBH5 siRNA - orb270801 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALKBH5 shRNA Plasmid (Human) - CHJ0300 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ALKBH5 miRNA 3'UTR clone - MiUTR1H-00307 from Creative biogene

Species Reactivities Human
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