| Gene Symbol |
AKR7A3
|
| Entrez Gene |
22977
|
| Alt Symbol |
AFAR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
|
| Other Description |
AFB1 aldehyde reductase 2|AFB1-AR 2|aflatoxin B1 aldehyde reductase 2|aflatoxin B1 aldehyde reductase member 3
|
| Swissprots |
Q9NUC3 O95154 Q8N5V6 Q8TAX1 Q86SR4 Q8IVN6
|
| Accessions |
EAW94878 EAW94879 O95154 AA844782 AF040639 AAD02195 AJ271799 CAC81076 BC025709 AAH25709 BC031562 AAH31562 BC042420 AAH42420 BG747063 BM855386 BM920315 EU176235 ABW03686 EU176541 ABW03342 EU831806 ACE87324 EU831883 ACE86642 XM_011541046 XP_011539348 XM_011541047 XP_011539349 NM_012067 NP_036199
|
| Function |
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:18416522}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. {ECO:0000269|PubMed:12879023, ECO:0000269|PubMed:18416522}.
|
| Top Pathways |
Metabolism of xenobiotics by cytochrome P450
|