Gene Symbol | AKR7A3 |
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Entrez Gene | 22977 |
Alt Symbol | AFAR2 |
Species | Human |
Gene Type | protein-coding |
Description | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) |
Other Description | AFB1 aldehyde reductase 2|AFB1-AR 2|aflatoxin B1 aldehyde reductase 2|aflatoxin B1 aldehyde reductase member 3 |
Swissprots | Q9NUC3 O95154 Q8N5V6 Q8TAX1 Q86SR4 Q8IVN6 |
Accessions | EAW94878 EAW94879 O95154 AA844782 AF040639 AAD02195 AJ271799 CAC81076 BC025709 AAH25709 BC031562 AAH31562 BC042420 AAH42420 BG747063 BM855386 BM920315 EU176235 ABW03686 EU176541 ABW03342 EU831806 ACE87324 EU831883 ACE86642 XM_011541046 XP_011539348 XM_011541047 XP_011539349 NM_012067 NP_036199 |
Function | Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:18416522}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. {ECO:0000269|PubMed:12879023, ECO:0000269|PubMed:18416522}. |
Top Pathways | Metabolism of xenobiotics by cytochrome P450 |
AKR7A3 CRISPR/Cas9 KO Plasmid (h) - sc-417458 from Santa Cruz Biotechnology
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AKR7A3 HDR Plasmid (h) - sc-417458-HDR from Santa Cruz Biotechnology
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AKR7A3 Double Nickase Plasmid (h) - sc-417458-NIC from Santa Cruz Biotechnology
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AKR7A3 Double Nickase Plasmid (h2) - sc-417458-NIC-2 from Santa Cruz Biotechnology
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AKR7A3 CRISPR Activation Plasmid (h) - sc-417458-ACT from Santa Cruz Biotechnology
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AKR7A3 CRISPR Activation Plasmid (h2) - sc-417458-ACT-2 from Santa Cruz Biotechnology
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AKR7A3 Lentiviral Activation Particles (h) - sc-417458-LAC from Santa Cruz Biotechnology
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AKR7A3 Lentiviral Activation Particles (h2) - sc-417458-LAC-2 from Santa Cruz Biotechnology
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AKR7A3 siRNA (h) - sc-105050 from Santa Cruz Biotechnology
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AKR7A3 shRNA Plasmid (h) - sc-105050-SH from Santa Cruz Biotechnology
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AKR7A3 shRNA (h) Lentiviral Particles - sc-105050-V from Santa Cruz Biotechnology
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AKR7A3 RNAi - H00022977-R01 from Novus Biologicals
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MISSION® esiRNA - EHU126881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3034 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3034 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01005 from Sigma-Aldrich
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AKR7A3 siRNA (Human) - CRH7901 from Cohesion Biosciences
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AKR7A3 - MBS8239599 from MyBioSource
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shRNA set against Human AKR7A3 (NM_012067.2) - SHH234630 from Creative biogene
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shRNA set against Human AKR7A3(NM_012067.2) - SHG051515 from Creative biogene
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Human AKR7A3 siRNA - orb268403 from Biorbyt
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AKR7A3 shRNA Plasmid (Human) - CHH7901 from Cohesion Biosciences
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AKR7A3 miRNA 3'UTR clone - MiUTR1H-00276 from Creative biogene
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