Gene Symbol | CCNO |
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Entrez Gene | 10309 |
Alt Symbol | CCNU, CILD29, UDG2 |
Species | Human |
Gene Type | protein-coding |
Description | cyclin O |
Other Description | cyclin U|cyclin domain containing|cyclin-O |
Swissprots | Q0P6J2 A8K1W5 Q9H6B0 P22674 Q9UMD5 |
Accessions | AAB05817 EAW54912 EAW54913 P22674 AK026075 BAB15351 AK290030 BAF82719 BC004877 AAH04877 BC017345 BC056254 BC143905 BC143907 BC160041 AAI60041 BI832060 BX096363 HY011414 X52486 CAA36728 NM_021147 NP_066970 NR_125346 NR_125347 NR_125348 NM_001024592 |
Function | Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:24747639}. Note=Localizes to the apical part of cytoplasm. {ECO:0000269|PubMed:24747639}. |
Tissue Specificity | Present in respiratory cells (at protein level). {ECO:0000269|PubMed:24747639}. |
cyclin O CRISPR/Cas9 KO Plasmid (h) - sc-407264 from Santa Cruz Biotechnology
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cyclin O HDR Plasmid (h) - sc-407264-HDR from Santa Cruz Biotechnology
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UDG2 Double Nickase Plasmid (h) - sc-407264-NIC from Santa Cruz Biotechnology
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cyclin O Double Nickase Plasmid (h2) - sc-407264-NIC-2 from Santa Cruz Biotechnology
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UDG2 CRISPR Activation Plasmid (h) - sc-407264-ACT from Santa Cruz Biotechnology
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cyclin O CRISPR Activation Plasmid (h2) - sc-407264-ACT-2 from Santa Cruz Biotechnology
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UDG2 Lentiviral Activation Particles (h) - sc-407264-LAC from Santa Cruz Biotechnology
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cyclin O Lentiviral Activation Particles (h2) - sc-407264-LAC-2 from Santa Cruz Biotechnology
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cyclin O siRNA (h) - sc-76802 from Santa Cruz Biotechnology
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cyclin O shRNA Plasmid (h) - sc-76802-SH from Santa Cruz Biotechnology
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cyclin O shRNA (h) Lentiviral Particles - sc-76802-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU095851 from Sigma-Aldrich
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MISSION® esiRNA - EHU158931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5648 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5648 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00838 from Sigma-Aldrich
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CCNO siRNA (Human) - CRH6984 from Cohesion Biosciences
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CCNO - MBS8240984 from MyBioSource
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shRNA set against Human CCNO (NM_021147.3) - SHH258029 from Creative biogene
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Human CCNO siRNA - orb267486 from Biorbyt
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CCNO shRNA Plasmid (Human) - CHH6984 from Cohesion Biosciences
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CCNO miRNA 3'UTR clone - MiUTR1H-01823 from Creative biogene
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