| Gene Symbol |
MYDGF
|
| Entrez Gene |
56005
|
| Alt Symbol |
C19orf10, EUROIMAGE1875335, IL25, IL27, IL27w, R33729_1, SF20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myeloid-derived growth factor
|
| Other Description |
UPF0556 protein C19orf10|interleukin 25|interleukin 27 working designation|interleukin-25|stromal cell-derived growth factor SF20
|
| Swissprots |
Q9NP69 O75256 Q969H8 O75272 Q9BTK7 D6W628
|
| Accessions |
AAC27824 AAC33800 EAW69202 EAW69203 Q969H8 AF282264 AK098829 AL365373 CAB96947 AL365374 CAB96948 BC003639 AAH03639 BC010129 AAH10129 BC014655 AAH14655 BG484758 NM_019107 NP_061980
|
| Function |
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250|UniProtKB:Q9CPT4, ECO:0000269|PubMed:25581518}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17362502}. Note=Secreted into blood plasma. {ECO:0000269|PubMed:25581518}.
|
| Tissue Specificity |
Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502). {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}.
|
