| Gene Symbol |
TIMM10B
|
| Entrez Gene |
26515
|
| Alt Symbol |
FXC1, TIM10B, Tim9b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
translocase of inner mitochondrial membrane 10 homolog B (yeast)
|
| Other Description |
fracture callus 1 homolog|fracture callus protein 1|mitochondrial import inner membrane translocase subunit Tim10 B|mitochondrial import inner membrane translocase subunit Tim9 B
|
| Swissprots |
Q9Y5J6 Q96FF3
|
| Accessions |
EAW68706 Q9Y5J6 AF150105 AAD40011 AF152355 AAF15105 AF183415 AAG09684 AI052126 AK002130 BAG51018 AK058048 AK311763 BAG34706 BC011014 AAH11014 DA290694 NM_012192 NP_036324
|
| Function |
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.
|
| Tissue Specificity |
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10611480, ECO:0000269|PubMed:14726512}.
|
![Western Blot: FXC1 Overexpression Lysate (Adult Normal) [NBL1-10870] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FXC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13703_FXC1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-10870-img0002.jpg)