Gene Symbol | TIMM10B |
---|---|
Entrez Gene | 26515 |
Alt Symbol | FXC1, TIM10B, Tim9b |
Species | Human |
Gene Type | protein-coding |
Description | translocase of inner mitochondrial membrane 10 homolog B (yeast) |
Other Description | fracture callus 1 homolog|fracture callus protein 1|mitochondrial import inner membrane translocase subunit Tim10 B|mitochondrial import inner membrane translocase subunit Tim9 B |
Swissprots | Q9Y5J6 Q96FF3 |
Accessions | EAW68706 Q9Y5J6 AF150105 AAD40011 AF152355 AAF15105 AF183415 AAG09684 AI052126 AK002130 BAG51018 AK058048 AK311763 BAG34706 BC011014 AAH11014 DA290694 NM_012192 NP_036324 |
Function | Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}. |
Tissue Specificity | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10611480, ECO:0000269|PubMed:14726512}. |