Gene Symbol | TIMM10B |
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Entrez Gene | 26515 |
Alt Symbol | FXC1, TIM10B, Tim9b |
Species | Human |
Gene Type | protein-coding |
Description | translocase of inner mitochondrial membrane 10 homolog B (yeast) |
Other Description | fracture callus 1 homolog|fracture callus protein 1|mitochondrial import inner membrane translocase subunit Tim10 B|mitochondrial import inner membrane translocase subunit Tim9 B |
Swissprots | Q9Y5J6 Q96FF3 |
Accessions | EAW68706 Q9Y5J6 AF150105 AAD40011 AF152355 AAF15105 AF183415 AAG09684 AI052126 AK002130 BAG51018 AK058048 AK311763 BAG34706 BC011014 AAH11014 DA290694 NM_012192 NP_036324 |
Function | Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}. |
Tissue Specificity | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10611480, ECO:0000269|PubMed:14726512}. |
Tim9B CRISPR/Cas9 KO Plasmid (h) - sc-417712 from Santa Cruz Biotechnology
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Tim9B HDR Plasmid (h) - sc-417712-HDR from Santa Cruz Biotechnology
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Tim9B Double Nickase Plasmid (h) - sc-417712-NIC from Santa Cruz Biotechnology
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Tim9B Double Nickase Plasmid (h2) - sc-417712-NIC-2 from Santa Cruz Biotechnology
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Tim9B CRISPR Activation Plasmid (h) - sc-417712-ACT from Santa Cruz Biotechnology
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Tim9B CRISPR Activation Plasmid (h2) - sc-417712-ACT-2 from Santa Cruz Biotechnology
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Tim9B Lentiviral Activation Particles (h) - sc-417712-LAC from Santa Cruz Biotechnology
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Tim9B Lentiviral Activation Particles (h2) - sc-417712-LAC-2 from Santa Cruz Biotechnology
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Tim9B siRNA (h) - sc-41253 from Santa Cruz Biotechnology
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Tim9B shRNA Plasmid (h) - sc-41253-SH from Santa Cruz Biotechnology
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Tim9B shRNA (h) Lentiviral Particles - sc-41253-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9007 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9007 from Sigma-Aldrich
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TIMM10B siRNA (Human) - CRH8842 from Cohesion Biosciences
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TIMM10B - MBS8200296 from MyBioSource
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shRNA set against Human FXC1 (NM_012192.3) - SHH297873 from Creative biogene
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shRNA set against Human FXC1(NM_012192.3) - SHH071021 from Creative biogene
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Human TIMM10B siRNA - orb269344 from Biorbyt
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TIMM10B shRNA Plasmid (Human) - CHH8842 from Cohesion Biosciences
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FXC1 miRNA 3'UTR clone - MiUTR1H-03885 from Creative biogene
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