| Gene Symbol |
RCC1
|
| Entrez Gene |
1104
|
| Alt Symbol |
CHC1, RCC1-I, SNHG3-RCC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of chromosome condensation 1
|
| Other Description |
SNHG3-RCC1 readthrough|cell cycle regulatory protein|guanine nucleotide-releasing protein|regulator of chromosome condensation
|
| Swissprots |
Q6NT97 Q16269 P18754
|
| Accessions |
BAA00469 EAX07690 EAX07691 EAX07692 EAX07693 EAX07694 EAX07695 P18754 AF498924 AAM21072 AI198971 BC001589 BC010067 AAH10067 BC069198 AAH69198 BF590413 BF667678 BM546148 BQ436549 BU501614 BU622451 BX109495 CB985055 CR407693 CAG28621 CV811053 DQ893153 ABM84079 DQ896760 ABM87759 S75708 AAB32653 X12654 CAA31182 NM_001048194 NP_001041659 NM_001048195 NP_001041660 NM_001048199 NP_001041664 NM_001269 NP_001260 NR_030725 NR_030726
|
| Function |
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. {ECO:0000269|PubMed:1944575}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17435751}. Cytoplasm {ECO:0000269|PubMed:17435751}. Note=Becomes dispersed throughout the cytoplasm during mitosis.
|
![Western Blot: RCC1 Overexpression Lysate (Adult Normal) [NBL1-15242] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RCC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11988_RCC1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-15242-img0002.jpg)
![Western Blot: RCC1 Overexpression Lysate (Adult Normal) [NBP2-08344] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RCC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5218_RCC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08344-img0001.jpg)