PPM1B

Gene Symbol	PPM1B
Entrez Gene	5495
Alt Symbol	PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Species	Human
Gene Type	protein-coding
Description	protein phosphatase, Mg2+/Mn2+ dependent, 1B
Other Description	Ser/Thr protein phosphatase type 2C beta 2 isoform|protein phosphatase 1B|protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform|protein phosphatase 2C-like protein
Swissprots	Q461Q2 Q96ER6 Q658R4 Q4J6C2 Q9HAY8 O75688 Q4J6C1
Accessions	AAX88954 EAX00280 EAX00281 EAX00282 EAX00283 O75688 AA742374 AA769851 AF136972 AAG49433 AF294792 AAG02232 AJ005801 CAA06704 AJ271832 CAC27992 AJ271835 CAC27993 AK056009 BAG51602 AK291214 BAF83903 AL833035 CAH56319 BC012002 AAH12002 BC064381 AAH64381 BF979498 BQ773881 DA128532 DQ023508 AAY89639 DQ023509 AAY89640 DQ023510 AAY89641 DQ023511 AAY89642 HQ448711 ADQ33189 XM_011532936 XP_011531238 NM_001033557 NP_001028729 NM_002706 NP_002697 NM_177968 NP_808907 NM_177969 NP_808908 NM_001033556
Function	Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
Tissue Specificity	Highly expressed in heart and skeletal muscle.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPM1B-Over-expression-Lysate - LY13871a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PPM1B 293T Cell Transient Overexpression Lysate(Denatured) - H00005495-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PPM1B overexpression lysate - LY406063 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PPM1B overexpression lysate - LY419156 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PPM1B 293 Cell Lysate - 403800 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PPM1B 293 Cell Lysate - 408965 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

PP2C beta/PPM1B Overexpression Lysate (Denatured) - H00005495-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PP2C beta/PPM1B Overexpression Lysate (Native) - NBL1-14659 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PP2Cβ (h2): 293T Lysate - sc-116891 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PPM1B Over-expression Lysate Product - GWB-801F43 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

PPM1B Over-expression Lysate Product - GWB-28296E from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

PP2C beta/PPM1B Overexpression Lysate (Native) - NBP2-05005 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human PPM1B Knockdown Stable Cell Line - CSC-DC012213 from Creative biogene Category Cell Line Species Human

Human PPM1B Knockout Cell Line-HEK293T - CSC-RT1153 from Creative biogene Category Cell Line Species Human

PPM1B KO Cell Lysate-HEK293T - CLKO-0648 from Creative biogene Category Cell Lysate

Search more