PPM1B

Gene Symbol	PPM1B
Entrez Gene	5495
Alt Symbol	PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Species	Human
Gene Type	protein-coding
Description	protein phosphatase, Mg2+/Mn2+ dependent, 1B
Other Description	Ser/Thr protein phosphatase type 2C beta 2 isoform|protein phosphatase 1B|protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform|protein phosphatase 2C-like protein
Swissprots	Q461Q2 Q96ER6 Q658R4 Q4J6C2 Q9HAY8 O75688 Q4J6C1
Accessions	AAX88954 EAX00280 EAX00281 EAX00282 EAX00283 O75688 AA742374 AA769851 AF136972 AAG49433 AF294792 AAG02232 AJ005801 CAA06704 AJ271832 CAC27992 AJ271835 CAC27993 AK056009 BAG51602 AK291214 BAF83903 AL833035 CAH56319 BC012002 AAH12002 BC064381 AAH64381 BF979498 BQ773881 DA128532 DQ023508 AAY89639 DQ023509 AAY89640 DQ023510 AAY89641 DQ023511 AAY89642 HQ448711 ADQ33189 XM_011532936 XP_011531238 NM_001033557 NP_001028729 NM_002706 NP_002697 NM_177968 NP_808907 NM_177969 NP_808908 NM_001033556
Function	Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
Tissue Specificity	Highly expressed in heart and skeletal muscle.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PPM1B-cDNA-Clone - DC03269 from Abgent, a WuXi AppTec company Prices $259.20 Sizes 10 µg Species Human Accession BC012002

PPM1B - MBS1276670 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC012002

Human PPM1B cDNA clone(NM_177968.2) - CDFG011429 from Creative Biomart Species Human Accession NM_177968.2

Human PPM1B cDNA clone(NM_177969.2) - CDFG011433 from Creative Biomart Species Human Accession NM_177969.2

Human PPM1B cDNA clone(NM_001033556.1) - CDFH014856 from Creative Biomart Species Human Accession NM_001033556.1

Human PPM1B cDNA clone(NM_001033557.1) - CDFH014857 from Creative Biomart Species Human Accession NM_001033557.1

Human PPM1B ORF Clone(NM_177968.2) - CDCR323035 from Creative Biomart Species Human Accession NM_177968.2

Human PPM1B ORF Clone(NM_177968.2) - CDCR323036 from Creative Biomart Species Human Accession NM_177968.2

Human PPM1B ORF Clone(NM_177968.2) - CDCR323037 from Creative Biomart Species Human Accession NM_177968.2

Human PPM1B ORF Clone(NM_177969.2) - CDCR323038 from Creative Biomart Species Human Accession NM_177969.2

Human PPM1B ORF Clone(NM_177969.2) - CDCR323039 from Creative Biomart Species Human Accession NM_177969.2

Human PPM1B ORF Clone(NM_001033556.1) - CDCR343143 from Creative Biomart Species Human Accession NM_001033556.1

Human PPM1B ORF Clone(NM_001033556.1) - CDCR343144 from Creative Biomart Species Human Accession NM_001033556.1

Human PPM1B ORF Clone(NM_001033557.1) - CDCR343145 from Creative Biomart Species Human Accession NM_001033557.1

Human PPM1B ORF Clone(NM_001033557.1) - CDCR343146 from Creative Biomart Species Human Accession NM_001033557.1

Human PPM1B Gene ORF cDNA clone in cloning vector - HG12224-G from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12224-NF from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12224-NM from Sino Biological Species Human

Human PPM1B Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-tagged - HG12224-CF from Sino Biological Species Human Accession BC012002

Human PPM1B Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12224-CM from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid, C-HA tag - HG12224-CY from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid, N-His tag - HG12224-NH from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid, N-HA tag - HG12224-NY from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid - HG12224-UT from Sino Biological Species Human

Human PPM1B Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12224-ANG from Sino Biological Species Human

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