| Gene Symbol |
CHRDL1
|
| Entrez Gene |
91851
|
| Alt Symbol |
CHL, MGC1, MGCN, NRLN1, VOPT, dA141H5.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chordin-like 1
|
| Other Description |
chordin-like protein 1|neuralin 1|neuralin-1|neurogenesin-1|ventroptin
|
| Swissprots |
Q539E4 B1AKD0 Q9Y3H7 Q9BU40 E9PGS5 D3DUY6 B4DMP3
|
| Accessions |
EAX02655 EAX02656 EAX02657 Q9BU40 AA057564 AB209548 BAD92785 AK092245 BAG52508 AK293106 BAF85795 AK297563 BAG59955 AK312270 AY608914 AAU25841 BC002909 AAH02909 BP377491 DC404314 XM_005262221 XP_005262278 XM_005262222 XP_005262279 XM_005262223 XP_005262280 XM_005262224 XP_005262281 NM_001143981 NP_001137453 NM_001143982 NP_001137454 NM_001143983 NP_001137455 NM_145234 NP_660277
|
| Function |
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. {ECO:0000250, ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. {ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.
|
![Western Blot: CHRDL1 Overexpression Lysate (Adult Normal) [NBL1-09171] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHRDL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2994_CHRDL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09171-img0002.jpg)