CHRDL1
| Gene Symbol | CHRDL1 |
|---|---|
| Entrez Gene | 91851 |
| Alt Symbol | CHL, MGC1, MGCN, NRLN1, VOPT, dA141H5.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chordin-like 1 |
| Other Description | chordin-like protein 1|neuralin 1|neuralin-1|neurogenesin-1|ventroptin |
| Swissprots | Q539E4 B1AKD0 Q9Y3H7 Q9BU40 E9PGS5 D3DUY6 B4DMP3 |
| Accessions | EAX02655 EAX02656 EAX02657 Q9BU40 AA057564 AB209548 BAD92785 AK092245 BAG52508 AK293106 BAF85795 AK297563 BAG59955 AK312270 AY608914 AAU25841 BC002909 AAH02909 BP377491 DC404314 XM_005262221 XP_005262278 XM_005262222 XP_005262279 XM_005262223 XP_005262280 XM_005262224 XP_005262281 NM_001143981 NP_001137453 NM_001143982 NP_001137454 NM_001143983 NP_001137455 NM_145234 NP_660277 |
| Function | Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. {ECO:0000250, ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. {ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}. |
CHRDL1 CRISPR/Cas9 KO Plasmid (h) - sc-407553 from Santa Cruz Biotechnology
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CHRDL1 HDR Plasmid (h) - sc-407553-HDR from Santa Cruz Biotechnology
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CHRDL1 Double Nickase Plasmid (h) - sc-407553-NIC from Santa Cruz Biotechnology
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CHRDL1 Double Nickase Plasmid (h2) - sc-407553-NIC-2 from Santa Cruz Biotechnology
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CHRDL1 CRISPR Activation Plasmid (h) - sc-407553-ACT from Santa Cruz Biotechnology
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CHRDL1 CRISPR Activation Plasmid (h2) - sc-407553-ACT-2 from Santa Cruz Biotechnology
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CHRDL1 Lentiviral Activation Particles (h) - sc-407553-LAC from Santa Cruz Biotechnology
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CHRDL1 Lentiviral Activation Particles (h2) - sc-407553-LAC-2 from Santa Cruz Biotechnology
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CHRDL1 siRNA (h) - sc-91247 from Santa Cruz Biotechnology
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CHRDL1 shRNA Plasmid (h) - sc-91247-SH from Santa Cruz Biotechnology
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CHRDL1 shRNA (h) Lentiviral Particles - sc-91247-V from Santa Cruz Biotechnology
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CHRDL1 siRNA (h) - sc-106949 from Santa Cruz Biotechnology
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CHRDL1 shRNA Plasmid (h) - sc-106949-SH from Santa Cruz Biotechnology
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CHRDL1 shRNA (h) Lentiviral Particles - sc-106949-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU040751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6088 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6088 from Sigma-Aldrich
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CHRDL1 siRNA (Human) - CRJ4085 from Cohesion Biosciences
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Chordin-like 1/CHRDL1 RNAi - H00091851-R01 from Novus Biologicals
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CHRDL1 - MBS8206537 from MyBioSource
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shRNA set against Human CHRDL1 (NM_145234.3) - SHH263417 from Creative biogene
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Human CHRDL1 siRNA - orb274586 from Biorbyt
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CHRDL1 shRNA Plasmid (Human) - CHJ4085 from Cohesion Biosciences
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CHRDL1 miRNA 3'UTR clone - MiUTR4H-TG02096 from Creative biogene
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