Gene Symbol | GADD45A |
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Entrez Gene | 1647 |
Alt Symbol | DDIT1, GADD45 |
Species | Human |
Gene Type | protein-coding |
Description | growth arrest and DNA-damage-inducible, alpha |
Other Description | DDIT-1|DNA damage-inducible transcript 1 protein|DNA damage-inducible transcript-1|DNA-damage-inducible transcript 1|growth arrest and DNA damage-inducible protein GADD45 alpha|growth arrest and DNA-damage-inducible 45 alpha |
Swissprots | Q5TCA8 Q5TCA7 P24522 |
Accessions | AAA72045 AAM88884 CBX53896 EAX06487 EAX06488 P24522 AK314991 BAG37487 AM393439 CAL38317 BC011757 AAH11757 BU629410 DQ008445 AAY25021 DQ893229 ABM84155 DQ896558 ABM87557 EF581092 ABQ52427 EF614238 M60974 AAA35863 NM_001199741 NP_001186670 NM_001199742 NP_001186671 NM_001924 NP_001915 |
Function | In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:7973727}. |
Top Pathways | Cell cycle, p53 signaling pathway, MAPK signaling pathway |
GADD45A-Over-expression-Lysate - LY10984a from Abgent, a WuXi AppTec company
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GADD45A overexpression lysate - LY419659 from Acris Antibodies
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GADD45A 293 Cell Lysate - 409201 from ABBIOTEC
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GADD45 alpha Overexpression Lysate (Native) - NBL1-10934 from Novus Biologicals
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GADD45A Over-expression Lysate Product - GWB-F3A05F from Genway Biotech
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Human GADD45A / DDIT-1 Insect Cell Lysate (WB positive control) - 11156-H20BL-300 from Sino Biological
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GADD45 alpha Overexpression Lysate (Denatured) - H00001647-T02 from Novus Biologicals
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GADD45 alpha Overexpression Lysate (Denatured) - H00001647-T01 from Novus Biologicals
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Human GADD45A Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175051 from Biorbyt
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Panoply™ Human GADD45A Knockdown Stable Cell Line - CSC-DC006035 from Creative biogene
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Human GADD45A Knockout Cell Line-HeLa - CSC-RT0583 from Creative biogene
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GADD45A KO Cell Lysate-HeLa - CLKO-0088 from Creative biogene
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