APOBEC3A

Gene Symbol APOBEC3A
Entrez Gene 200315
Alt Symbol A3A, ARP3, PHRBN, bK150C2.1
Species Human
Gene Type protein-coding
Description apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
Other Description DNA dC->dU-editing enzyme APOBEC-3A|phorbolin 1|phorbolin-1|probable DNA dC->dU-editing enzyme APOBEC-3A
Swissprots Q5JZ93 A0AVM1 P31941 Q12807 Q9UH18
Accessions EAW60278 P31941 BC126416 AAI26417 BC144146 AAI44147 BI029063 CR456393 CAG30279 CU012950 CAK54381 CU013238 CAK54680 DB322320 HQ258100 ADR82854 U03891 AAA03706 NM_001270406 NP_001257335 NM_145699 NP_663745
Function DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20308164}.

APOBEC3A CRISPR/Cas9 KO Plasmid (h) - sc-418267 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A HDR Plasmid (h) - sc-418267-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A Double Nickase Plasmid (h) - sc-418267-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A Double Nickase Plasmid (h2) - sc-418267-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A CRISPR Activation Plasmid (h) - sc-418267-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A CRISPR Activation Plasmid (h2) - sc-418267-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A Lentiviral Activation Particles (h) - sc-418267-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A Lentiviral Activation Particles (h2) - sc-418267-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3A siRNA (h) - sc-72514 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APOBEC3A shRNA Plasmid (h) - sc-72514-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APOBEC3A shRNA (h) Lentiviral Particles - sc-72514-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU031571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3334 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3334 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05823 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05823

APOBEC3A siRNA (Human) - CRJ6245 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human APOBEC3A (NM_145699.3) - SHH238430 from Creative biogene

Category siRNA
Species Reactivities Human

APOBEC3A shRNA Plasmid (Human) - CHJ6245 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APOBEC3A miRNA 3'UTR clone - MiUTR4H-TG00414 from Creative biogene

Species Reactivities Human
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