KSR2

Gene Symbol	KSR2
Entrez Gene	283455
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	kinase suppressor of ras 2
Other Description	kinase suppressor of Ras 2
Swissprots	A0PJT2 Q6VAB6 Q8N775 Q3B828
Accessions	CAH68720 EAW98111 EAW98112 Q6VAB6 AK098831 BAC05426 AY345972 AAQ24226 BC107106 AAI07107 BC107107 AAI07108 BC127603 AAI27604 BX648958 DW009880 DW009881 XM_011538224 XP_011536526 XM_011538225 XP_011536527 XM_011538226 XP_011536528 XM_011538227 XP_011536529 XM_011538228 XP_011536530 XM_011538229 XP_011536531 XM_011538230 XP_011536532 XR_944522 NM_173598 NP_775869
Function	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Mainly expressed in brain and kidney. {ECO:0000269|PubMed:12975377}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KSR2 (mutated R676 S) protein fragment - ab184730 from Abcam Category Protein Prices $362.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human KSR2 protein fragment - ab185259 from Abcam Category Protein Prices $362.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human KSR2 full length protein - ab166135 from Abcam Category Protein Source Wheat germ Species Human

Human KSR2 protein fragment - ab166136 from Abcam Category Protein Source Wheat germ Species Human

KSR2 Antibody Blocking Peptide - LS-E991 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KSR2 Antibody Blocking Peptide - LS-E3453 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KSR2 Protein - H00283455-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human KSR2 Protein - H00283455-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KSR2-Antibody-C-term-Blocking-peptide - BP11443b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Kinase suppressor of Ras 2 - H00283455-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Kinase suppressor of Ras 2 - H00283455-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Kinase suppressor of Ras 2 - H00283455-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human KSR2 Mutant (R676S), GST-tagged - KSR2-83H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human KSR2, GST-tagged - KSR2-82H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Ksr2 (I694) Peptide - BS2321P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Kinase suppressor of Ras 2(KSR2) ,partial - CSB-YP012696HU CSB-EP012696HU CSB-BP012696HU CSB-MP012696HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KSR2 Recombinant Protein Antigen - NBP1-83553PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KSR2 Peptide, Human - M34GP08495H from Creative Peptides Category Peptide Source Synthetic. Species Human

Kinase suppressor of Ras 2 (KSR2), partial, Recombinant Protein - MBS1425463 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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