| Gene Symbol |
Pla2g2c
|
| Entrez Gene |
18781
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group IIC
|
| Other Description |
14 kDa phospholipase A2|GIIC sPLA2|PLA2-8|group IIC secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2C|sPLA2-IIC
|
| Swissprots |
P48076
|
| Accessions |
EDL13275 P48076 BC029347 AAH29347 CA464794 U18119 AAC52936 NM_008868 NP_032894
|
| Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Testis PA2 may be important in the production of prostaglandins, by the release of arachidonic acid, which in turn are necessary for the contractions of the seminiferous tubules and the testicular capsule; they also seem to decrease sperm transit time through the male reproductive tract.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Testis specific.
|
| Top Pathways |
Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism
|