TRMU

Gene Symbol	TRMU
Entrez Gene	55687
Alt Symbol	MTO2, MTU1, TRMT, TRMT1, TRNT1
Species	Human
Gene Type	protein-coding
Description	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Other Description	MTO2 homolog|mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase|mitochondrial tRNA-specific 2-thiouridylase 1
Swissprots	Q9NWC1 Q6ICC3 Q66K31 A8K3U7 Q05C99 Q5W9C8 O75648
Accessions	AAL35970 EAW73422 EAW73423 EAW73424 EAW73425 EAW73426 O75648 AB178028 BAD66875 AK000212 AK001002 BAA91462 AK055295 AK093743 AK290712 BAF83401 AK295173 BAG58183 AK303020 BAG64147 AY062123 AAL38183 BC012076 BC027991 AAH27991 BC066593 BC080631 AAH80631 BM755897 BX952612 CN365141 CR456445 CAG30331 CU013043 CAK54474 CU013331 CAK54773 DN997542 DQ309998 ABC46690 DQ309999 ABC46691 DQ310000 ABC46692 XM_005261678 XP_005261735 XM_005261681 XP_005261738 XM_011530271 XP_011528573 XM_011530272 XP_011528574 XM_011530273 XP_011528575 XM_011530274 XP_011528576 XM_011530275 XP_011528577 NM_001282782 NP_001269711 NM_001282783 NP_001269712 NM_001282784 NP_001269713 NM_001282785 NP_001269714 NM_018006 NP_060476 NR_104240 NR_104241 NM_001008569 NM_001008571
Function	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. {ECO:0000269|PubMed:15509579, ECO:0000269|PubMed:15944150, ECO:0000269|PubMed:16826519}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:15509579, ECO:0000269|PubMed:15944150, ECO:0000269|PubMed:16513084, ECO:0000269|PubMed:16826519}.
Tissue Specificity	Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain. {ECO:0000269|PubMed:16513084}.
Top Pathways	Sulfur relay system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRMT1 full length protein - ab163178 from Abcam Category Protein Source Wheat germ Species Human

Human TRNT1 full length protein - ab162412 from Abcam Category Protein Source Wheat germ Species Human

TRMU Antibody Blocking Peptide - LS-E6378 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRMU Antibody Blocking Peptide - LS-E17648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRNT1 / CCA1 Antibody Blocking Peptide - LS-E14962 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRMU Protein - H00055687-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TRNT1 Protein - H00051095-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

TRMU-Antibody-Center-Blocking-Peptide - BP19094c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRMU Blocking Peptide - 33R-1321 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRNT1 Blocking Peptide - 33R-7294 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRMU / TRMT1 - H00055687-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRMU / TRMT1 - H00055687-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRNT1 - H00051095-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

TRMU fusion protein - ag21930 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Mitochondrial tRNA-specific 2-thiouridylase 1(TRMU) - CSB-YP024545HU CSB-EP024545HU CSB-BP024545HU CSB-MP024545HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRMU / TRMT1 (transcript variant 1) - TP319032 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TRMU Recombinant Protein Antigen - NBP1-87923PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRNT1 Recombinant Protein Antigen - NBP1-86589PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRMU Peptide, Human - M34GP16663H from Creative Peptides Category Peptide Source Synthetic. Species Human

TRNT1 Peptide, Human - M34GP16666H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU), Recombinant Protein - MBS1116717 from MyBioSource Category Protein Prices $1,195.00, $1,195.00, $1,415.00, $1,415.00, $1,930.00, $1,930.00, $2,395.00, $2,395.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU), Recombinant Protein - MBS1350784 from MyBioSource Category Protein Prices $1,195.00, $1,195.00, $1,415.00, $1,415.00, $1,930.00, $1,930.00, $2,395.00, $2,395.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

TRMU Recombinant Protein Antigen - NBP2-58360PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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