DSCAM

Gene Symbol	DSCAM
Entrez Gene	1826
Alt Symbol	CHD2, CHD2-42, CHD2-52
Species	Human
Gene Type	protein-coding
Description	Down syndrome cell adhesion molecule
Other Description	-
Swissprots	O60469 O60468
Accessions	CAB90436 CAB90444 CAB90464 EAX09620 EAX09621 O60469 AB209136 BAD92373 AF023449 AAC17966 AF023450 AAC17967 AF086100 AF217525 AAF27525 AF289030 AAL56711 BE503065 XM_011529480 XP_011527782 XM_011529481 XP_011527783 NM_001271534 NP_001258463 NM_001389 NP_001380 NR_073202
Function	Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. {ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:15169762, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}.
Subcellular Location	Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. {ECO:0000250}.
Tissue Specificity	Primarily expressed in brain.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Down syndrome cell adhesion molecule, ELISA Kit - MBS9327588 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10ng/ml. Range 3.12ng/ml-100ng/ml.

Custom Human DSCAM ELISA - ELH-DSCAM from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human DSCAM ELISA - RAB1423 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Custom Human DSCAM ELISA - ELH-DSCAM-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human DSCAM ELISA Kit - E012363 from Biobool Category ELISA Kit

anti-DSCAM antibody - ARG64036 from Arigo Biolaboratories Category ELISA Kit

Down Syndrome Cell Adhesion Molecule (DSCAM), ELISA Kit - MBS9375505 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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