DSCAM

Gene Symbol	DSCAM
Entrez Gene	1826
Alt Symbol	CHD2, CHD2-42, CHD2-52
Species	Human
Gene Type	protein-coding
Description	Down syndrome cell adhesion molecule
Other Description	-
Swissprots	O60469 O60468
Accessions	CAB90436 CAB90444 CAB90464 EAX09620 EAX09621 O60469 AB209136 BAD92373 AF023449 AAC17966 AF023450 AAC17967 AF086100 AF217525 AAF27525 AF289030 AAL56711 BE503065 XM_011529480 XP_011527782 XM_011529481 XP_011527783 NM_001271534 NP_001258463 NM_001389 NP_001380 NR_073202
Function	Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. {ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:15169762, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}.
Subcellular Location	Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. {ECO:0000250}.
Tissue Specificity	Primarily expressed in brain.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Dscam peptide - ab43846 from Abcam Category Peptide

Human Dscam protein fragment - ab116817 from Abcam Category Protein Source Wheat germ Species Human

DSCAM Antibody Blocking Peptide - LS-E26149 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DSCAM Antibody Blocking Peptide - LS-E16538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DSCAM Protein - H00001826-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DSCAM blocking peptide - GTX89275-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human DSCAM, CF - 3666-DS-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu18-Met1595

DSCAM Blocking Peptide - 33R-6387 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DSCAM Peptide - AC21-0979-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DSCAM - H00001826-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DSCAM - H00001826-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DSCAM Peptide - 45-499P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

DSCAM fusion protein - ag13672 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DSCAM fusion protein - Ag13693 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DSCAM fusion protein - ag13671 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DSCAM fusion protein - ag13692 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DSCAM fusion protein - ag4248 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DSCAM, His-tagged - DSCAM-12170H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DSCAM - DSCAM-1000H from Creative Biomart Category Protein Source NSO Cells Species Human

Recombinant Human Down syndrome cell adhesion molecule(DSCAM) ,partial - CSB-YP007192HU CSB-EP007192HU CSB-BP007192HU CSB-MP007192HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human DSCAM Protein, CF - 3666-DS from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Glu18-Met1595 Species Human

DSCAM, Peptide - MBS426529 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

DSCAM Recombinant Protein Antigen - NBP2-30716PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DSCAM Peptide, Human - M34GP04557H from Creative Peptides Category Peptide Source Synthetic. Species Human

DSCAM Immunizing peptide - orb17205 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

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