DSCAM
| Gene Symbol | DSCAM |
|---|---|
| Entrez Gene | 1826 |
| Alt Symbol | CHD2, CHD2-42, CHD2-52 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Down syndrome cell adhesion molecule |
| Other Description | - |
| Swissprots | O60469 O60468 |
| Accessions | CAB90436 CAB90444 CAB90464 EAX09620 EAX09621 O60469 AB209136 BAD92373 AF023449 AAC17966 AF023450 AAC17967 AF086100 AF217525 AAF27525 AF289030 AAL56711 BE503065 XM_011529480 XP_011527782 XM_011529481 XP_011527783 NM_001271534 NP_001258463 NM_001389 NP_001380 NR_073202 |
| Function | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. {ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:15169762, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}. |
| Subcellular Location | Isoform Long: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. {ECO:0000250}. |
| Tissue Specificity | Primarily expressed in brain. |
DSCAM CRISPR/Cas9 KO Plasmid (h) - sc-403385 from Santa Cruz Biotechnology
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DSCAM HDR Plasmid (h) - sc-403385-HDR from Santa Cruz Biotechnology
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DSCAM Double Nickase Plasmid (h) - sc-403385-NIC from Santa Cruz Biotechnology
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DSCAM Double Nickase Plasmid (h2) - sc-403385-NIC-2 from Santa Cruz Biotechnology
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DSCAM CRISPR Activation Plasmid (h) - sc-403385-ACT from Santa Cruz Biotechnology
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DSCAM CRISPR Activation Plasmid (h2) - sc-403385-ACT-2 from Santa Cruz Biotechnology
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DSCAM Lentiviral Activation Particles (h) - sc-403385-LAC from Santa Cruz Biotechnology
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DSCAM Lentiviral Activation Particles (h2) - sc-403385-LAC-2 from Santa Cruz Biotechnology
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DSCAM siRNA (h) - sc-77182 from Santa Cruz Biotechnology
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DSCAM shRNA Plasmid (h) - sc-77182-SH from Santa Cruz Biotechnology
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DSCAM shRNA (h) Lentiviral Particles - sc-77182-V from Santa Cruz Biotechnology
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DSCAM RNAi - H00001826-R01 from Novus Biologicals
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MISSION® esiRNA - EHU004531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7498 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7498 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04588 from Sigma-Aldrich
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DSCAM siRNA (Human) - CRH1275 from Cohesion Biosciences
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DSCAM - MBS8202256 from MyBioSource
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shRNA set against Human DSCAM(NM_001389.3) - SHG174007 from Creative biogene
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DSCAM shRNA Plasmid (Human) - CHH1275 from Cohesion Biosciences
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DSCAM miRNA 3'UTR clone - MiUTR1H-03000 from Creative biogene
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