| Gene Symbol | LIMK1 |
|---|---|
| Entrez Gene | 3984 |
| Alt Symbol | LIMK, LIMK-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | LIM domain kinase 1 |
| Other Description | LIM motif-containing protein kinase |
| Swissprots | Q15821 B7Z6I8 Q75MU3 Q15820 D3DXF5 O15283 P53667 D3DXF4 Q9Y5Q1 |
| Accessions | AAB17545 AAB17546 AAC13885 AAC13886 AAS07436 AAS07437 AAS07438 EAW69620 EAW69621 EAW69622 EAW69623 P53667 AB209557 BAD92794 AF134379 AAD25742 AK026544 AK125156 AK290162 BAF82851 AK300382 BAH13274 AW016257 BC148340 AAI48341 BC152982 AAI52983 D26309 BAA05371 DC296332 NM_001204426 NP_001191355 NM_002314 NP_002305 NM_016735 |
| Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin- 2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phospho |
| Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. |
| Tissue Specificity | Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle. |
| Top Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton |