CRLS1

Gene Symbol CRLS1
Entrez Gene 54675
Alt Symbol C20orf155, CLS, CLS1, GCD10, dJ967N21.6
Species Human
Gene Type protein-coding
Description cardiolipin synthase 1
Other Description cardiolipin synthase (CMP-forming)
Swissprots Q69YQ5 E9PAT4 Q27RP0 D3DW09 Q9UJA2
Accessions EAX10399 EAX10400 EAX10401 EAX10402 Q9UJA2 AF241784 AAG44472 AK310368 AL832419 CAH10649 BC069010 AAH69010 BM763234 BP368984 DQ386730 ABD46888 XM_005260737 XP_005260794 XM_005260738 XP_005260795 XM_006723579 XP_006723642 XM_006723580 XP_006723643 XM_011529262 XP_011527564 XM_011529263 XP_011527565 XM_011529264 XP_011527566 XM_011529265 XP_011527567 NM_001127458 NP_001120930 NM_019095 NP_061968
Function Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. {ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:16547353}; Multi-pass membrane protein {ECO:0000269|PubMed:16547353}.
Tissue Specificity Highly expressed in tissues such as heart, skeletal muscle and liver. {ECO:0000269|PubMed:16547353}.
Top Pathways Glycerophospholipid metabolism

CLS1 (E-14) - sc-85488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CLS1 (W-16) - sc-85490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CRLS1 antibody - ab156882 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of CRLS1 staining in human heart formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab156882, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-CRLS1 antibody - ab179943 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue, labeling CRLS1 with ab179943 at 5 µg/ml.

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234, APC) - LS-C208669 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234, AP) - LS-C208667 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234, Biotin) - LS-C208670 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234, Azide-free, HRP) - LS-C208672 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234, FITC) - LS-C208671 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234, PE) - LS-C208673 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234) - LS-C320605 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa107-156) - LS-C116370 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRLS1 antibody LS-C116370 Western blot of Fetal Muscle lysate.

Anti-Cardiolipin Synthase / CRLS1 Antibody (Internal) IHC-plus™ - LS-B9167 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-Cardiolipin Synthase / CRLS1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-Cardiolipin Synthase / CRLS1 Antibody (aa205-234) - LS-C167049 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRLS1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.

CLS1 Antibody - NBP2-27464 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: CLS1 Antibody [NBP2-27464] - NBP2-27464 (0.2ug/ml) staining of HEK293 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CRLS1 antibody produced in rabbit - SAB2105727 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CRLS1: <B>Cat. No. SAB2105727</B>: CRLS1 in Fetal Muscle cell lysates with CRLS1 antibody at 1.0 μg/mL.

ANTI-CRLS1 (C-TERM) antibody produced in rabbit - SAB1303500 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CRLS1 (C-term): <B>Cat. No. SAB1303500</B>: CRLS1 in Human skeletal muscle tissue with CRLS1 antibody (C-term) at 5 μg/mL.

Anti-CRLS1 antibody produced in goat - SAB2501839 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CRLS1: <B>Cat. No. SAB2501839</B>: (0.2 μg/mL) staining of HEK293 lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CRLS1 antibody - middle region (ARP49444_P050) - ARP49444_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CRLS1 Antibody - C-terminal region (OAAB02838) - OAAB02838 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CRLS1-Antibody-C-term - AP5423b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CRLS1 Antibody (C-term) (Cat. #AP5423b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRLS1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

cardiolipin-synthase-1-Antibody-internal-region - AF3607a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3607a (0.2 µg/ml) staining of HEK293 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat anti-cardiolipin synthase 1 middle region Antibody (OAEB02858) - OAEB02858 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

CRLS1 antibody - 70R-16595 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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